Inhibitors of Cyclic AMP Phosphodiesterase in Picrasma quassioides BENNET, and Inhibitory Activities of Related β-Carboline Alkaloids
スポンサーリンク
概要
- 論文の詳細を見る
Cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitors present in Picrasma quassioides BENN. were identified as 1-methoxycarbonyl-β-carboline, 4,5-dimethoxycanthin-6-one and 5-hydroxy-4-methoxycanthin-6-one. The structure-inhibitory activity relationships were studied in 31 derivatives of β-carboline, 2 dimeric derivatives of β-carboline and 12 derivatives of canthin-6-one. β-Carboline derivatives with a methoxycarbonyl group and canthin-6-one derivatives with a methoxyl group generally had a strong inhibitory effect on cAMP phosphodiesterase.
- 公益社団法人日本薬学会の論文
- 1984-05-25
著者
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小池 一男
東邦大学薬学部
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三川 潮
Faculty of Pharmaceutical Sciences, University of Tokyo
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小池 一男
School of Pharmaceutical Sciences, Toho University
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大本 太一
School of Pharmaceutical Sciences, Toho University
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二階堂 保
School of Pharmaceutical Sciences, Toho University
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三川 潮
Faculty Of Pharmaceuical Sciences The University Of Tokyo
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小池 一男
東邦大・薬
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SUNG YEOLIK
School of Pharmaceutical Sciences, Toho University
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成 烈益
School of Pharmaceutical Sciences, Toho University
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小池 一男
School Of Pharmaceutical Sciences Toho University
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成 烈益
School Of Pharmaceutical Sciences Toho University
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