Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Alkaloids. II

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概要

• 論文の詳細を見る

• The structure-inhibitory activity relationships were studied in analogous alkaloids from Picrasma quassioides and Ailanthus altissima, and their derivatives. Altogether, 53 β-carboline, 18 canthinone and 7 dimeric alkaloids were tested for cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibition. Major alkaloids (10,63 and 74) among the three groups of congeners in Picrasma quassioides and Ailanthus altissima showed the most potent inhibitory activity, equal to or greater than that of papaverine used as a reference.

• 社団法人日本薬学会の論文
• 1988-11-25

著者

• 小池 一男

  東邦大学薬学部

• 三川 潮

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 小池 一男

  School of Pharmaceutical Sciences, Toho University

• 大本 太一

  School of Pharmaceutical Sciences, Toho University

• 二階堂 保

  School of Pharmaceutical Sciences, Toho University

• 三川 潮

  Faculty Of Pharmaceuical Sciences The University Of Tokyo

• 小池 一男

  東邦大・薬

• 大本 太一

  東邦大薬

• 三川 潮

  東大 薬

• 甲田 邦子

  School of Pharmaceutical Sciences, Toho University

• Sankawa U

  International Research Center For Traditional Medicine

• Sankawa Ushio

  (present Address)faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Sankawa Ushio

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 小池 一男

  School Of Pharmaceutical Sciences Toho University

• 甲田 邦子

  東邦大学薬学部

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