Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Lignan Glucosides of Eucommia Bark

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概要

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• Studies were conducted on adenosine 3', 5'-cyclic monophosphate (cyclic AMP) phosphodiesterase inhibition by lignan glucosides from bark of Eucommia ulmoides OLIV. (Eucommiaceae). Various lignan diglucosides. (+)-syringaresinol di-O-β-D-glucopyranoside (1c), (+)-medioresinol di-O-β-D-glucopyranoside (2c), (+)-pinoresinol di-O-β-D-glucopyranoside (3c) and (+)-1-hydroxy-pinoresinol 4', 4"-di-O-β-D-glucopyranoside (4d), showed strong inhibitory activity.The structure-inhibitory activity relationships of the aglycone and its glucosides are discussed. The order of inhibitory effect was diglucoside ≩︀ aglycone > monoglucoside.

• 社団法人日本薬学会の論文
• 1988-01-25

著者

• 三川 潮

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 西部 三省

  Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

• 荻原 幸夫

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 出山 武

  養命酒製造(株)中央研究所

• 大本 太一

  School of Pharmaceutical Sciences, Toho University

• 二階堂 保

  School of Pharmaceutical Sciences, Toho University

• 三川 潮

  Faculty Of Pharmaceuical Sciences The University Of Tokyo

• 荻原 幸夫

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 竹田 忠紘

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 出山 武

  Central Reseach Laboratories, Yomeishu Seizo Co., Ltd.,

• 北川 静香

  Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University

• 西部 三省

  Univ. Hokkaido Hokkaido Jpn

• 西部 三省

  北海道医療大 薬

• Nishibe Sansei

  Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University

• 西部 三省

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Takeda T

  Kyoritsu University Of Pharmacy

• 北川 静香

  Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University

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