Phenolic Compounds from Stem Bark of Acanthopanax senticosus and Their Pharmacological Effect in Chronic Swimming Stressed Rats
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概要
- 論文の詳細を見る
Ten phenolic compounds, isofraxidin (1), (+)-syringaresinol-di-O-β-D-glucoside (2), syringin (3), chlorogenic acid (4), isofraxidin-7-O-β-D-glucoside (5), 2,6-dimethoxy-p-benzoquinone (6), (+)-pinoresinol-O-β-D-glucoside (7), (+)-syringaresinol-O-β-D-glucoside (8), (+)-pinoresinol-di-O-β-D-glucoside (9), and (+)-medioresinol-di-O-β-D-glucoside (10), were isolated from the stem bark of Acanthopanax senticosus HARMS and identified, respectively.The aquenous extract of the stem bark exhibited a prolonging effect on the exercise time to exhaustion in chronic swimming stressed rats. The effect on the exercise time in the chronic swimming stressed rats was respectively tested for compounds 2 and 4,which are major constituents of the stem bark. As a result, it was indicated that compound 2 is the compound responsible for part of the pharmacological effect which the aqueous extract of the stem bark showed.
- 公益社団法人日本薬学会の論文
- 1990-06-25
著者
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西部 三省
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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武田 秀勝
札幌医科大学保健医療学部
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西部 三省
Univ. Hokkaido Hokkaido Jpn
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西部 三省
北海道医療大 薬
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Nishibe Sansei
Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University
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岡野 五郎
Sapporo Medical College
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木下 英弘
Faculty of Pharmaceutical Sciences
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武田 秀勝
Department of General Education
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西部 三省
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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木下 英弘
Faculty Of Pharmaceutical Sciences:higashi Nippon Gakuen University
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