EFFECTS OF SOME PHENOLICS ON THE PROSTAGLAND IN SYNTHESIZING ENZYME SYSTEM

スポンサーリンク

概要

• 論文の詳細を見る

• N-cis- and N-t__-r__-a__-n__-s__--feruloyltyramines were isolated as the inhibitors of prostaglandin (PG) biosynthesis from Ipomoea aquatica. Aromatic amides consisting of naturally occurring cinnamic acids and β-phenethylamines were synthesized and tested for their effects on PG biosynthesis. Of those caffeoyl-β-phenethylamine(CaP) stimulated PG biosynthesis at a lower concentration and inhibited at a higher concentration. It has been shown that CaP inhibits cyclooxygenase and stimulates peroxidase in PG biosynthesis. o__-- and m__--Hydroxycinnamic acids were found to act as "tryptophan-like cofactors" even at a very high concentration where p__--coumaric acid significantly inhibit PG biosynthesis.

• 社団法人日本薬学会の論文
• 1986-03-25

著者

• 三川 潮

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 合田 幸広

  国立医薬品食品衛生研究所

• 海老塚 豊

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 渋谷 雅明

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 三川 潮

  Faculty Of Pharmaceuical Sciences The University Of Tokyo

• 合田 幸広

  医薬品食品衛研

• 合田 幸広

  Faculty of Pharmaceutical Sciences. University of Tokyo

• 曽 千芳

  Faculty of Pharmaceutical Sciences, University of Tokyo

• Padmawinata Kosasih

  Department Of Pharmacy Faculty Of Science And Mathematics Bandung Institute Of Technology

• 三ケ尻 昭博

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 曽 千芳

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 三ケ尻 昭博

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

関連論文

• DART-TOF/MSを用いたポリ塩化ビニル中の可塑剤の検索およびフタル酸エステルのスクリーニング法の検討
• 多機能カラムとHPLCを利用した食品中のアフラトキシン分析法の応用と改良
• 漢方薬・生薬の品質保証 (今月の主題 漢方薬・生薬と臨床検査)
• 健康食品中から検出されたタダラフィル類縁物質の構造解析
• S1-03 日本薬局方と和漢薬の標準化(シンポジウム1 和漢薬標準化の内と外,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
• Inhibition of Phenylalanine Ammonia-lyase by Flavonoids
• Biosynthesis of Scytalone
• 国産穀物等から分離したFusarium moniliformeとF. proliferatumのフモニシン産生能及び新規フモニシン類の検出
• 生薬規格の国際調和 : 局方にみる生薬の基原植物
• 幻覚性植物Salvia divinorum及び近縁植物の成分と基原種鑑別について
• セイヨウサンザシ(Crataegus oxyacantha L.)葉の主成分並びに同植物葉及び市販セイヨウサンザシ葉製品の分析
• 既存添加物「ユーカリ葉抽出物」の主成分に関する研究
• 天然着色料アルカネット色素の主色素成分と基原種に関する研究
• 天然着色料アルカネット色素の主色素成分に関する研究
• HPLCによるモロヘイヤ (Corchorus olitorius) 及びその加工品中の Digitoxigenin 配糖体の分析
• 一般用漢方処方の使用実態調査AUR(Actual Use Research)およびAURを用いた加味逍遙散の特徴解析
• 西太平洋地区4カ国(日本、中国、韓国、ベトナム)の薬局方収載生薬の各種試験法並びに規格値の比較に関する研究(第2報) : 確認試験におけるTLC条件及び定量法における分析条件の比較
• ISOFLAVONE GLUCOSIDES EXIST AS THEIR 6"-O___--MALONYL ESTERS IN PUERARIA LOBATA AND ITS CELL SUSPENSION CULTURES
• ISOLATION, SEQUENCE AND BACTERIAL EXPRESSION OF A cDNA FOR CHALCONE SYNTHASE FROM THE CULTURED CELLS OF PUERARIA LOBATA
• Isoflavone Synthase from Cell Suspension Cultures of Pueraria lobata
• DEOXYCHALCONE SYNTHASE FROM CELL SUSPENSION CULTURES OF ___- ___-
• P-5 Taxodium属およびMaytenus属植物より単離した微小管重合阻害活性を有する新規ジテルペン、トリテルペンの構造と活性(ポスター発表の部)
• Convenient TLC-based Identification Test for the Crude Drug "Pogostemoni Herba"
• 2006年度買い上げ違法ドラッグ製品から検出されたデザイナードラッグ成分のNMRを中心とした分析
• 食品等にも使用される市販生薬類の残留二酸化硫黄と明度(L^*)及び彩度(C^*)との関係について
• 雪茶を例とした味認識装置による味のプロファイル分析
• 各種雪茶製品の含有成分並びにHPLCプロファイル分析に関する研究
• NON-STEREOSPECIFIC INCORPORATION OF (1,2- ^C_2)-ACETATE INTO TROPANE ALKALOIDS IN HYOSCYAMUS ALBUS
• Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Components of Sophora flavescens AITON
• The Structure of Paeoniflorigenone, A New Monoterpene isolated from Paeoniae Radix
• Biosynthesis of Natural Products. III. Biosynthesis of Erythroskyrine, A Coloring Matter of Penicillium islandicum SOPP.
• Metabolic Products of Fungi. XXIV. The Structure of Erythroskyrine, a Nitrogen-containing Coloring Matter of Penicillium islandicum Sopp
• Inhibitors of Prostaglandin Biosynthesis from Dalbergia odorifera
• Inhibition of Prostaglandin and Leukotriene Biosynthesis by Gingerols and Diarylheptanoids
• Chemical Studies on Sophora tomentosa : the Isolation of a New Class of Isoflavonoid
• Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids. III
• Constituents of the Leaves of Murraya paniculata Collected in Taiwan
• The Screening of Chinese Crude Drugs for Ca^ Antagonist Activity : Identifiaction of Active Principles from the Aerial Part of Pogostemon cablin and the Fruits of Prunus mume
• Constituents of the Root Bark of Murraya paniculata Collected in Indonesia
• PURIFICATION OF 2,3-OXIDOSQUALENE / CYCLOARTENOL CYCLASE FROM PEA SEEDLINGS
• Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Alkaloids. II
• Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids. II
• Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Lignan Glucosides of Eucommia Bark
• Inhibitors of Prostaglandin Biosynthesis from Mucuna birdwoodiana(Organic,Chemical)
• THE Ca^ ANTAGONIST ACTIVITY OF LIGNANS
• Inhibitors of the Arachidonate Cascade from Allium chinense and Their Effect on in Vitro Platelet Aggregation(Organic,Chemical)
• Inhibitors of Adenosine 3',5'-Cyclic Monophosphate Phosphodiesterase in Daphne genkwa SIEB. et ZUCC(Pharmacognosy,Chemical)
• ACID-CATALYZED REARRANGEMENT OF AN EPOXY COUMARIN PHEBALOSIN THE REVISED STRUCTURE OF MURRALONGIN
• INHIBITION OF ARACHIDONATE 5-LIPOXYGENASE BY PHENOLIC COMPOUNDS
• THE ISOLATION OF A NEW CLASS OF ISOFLAVONOID METABOLITES FROM SOPHORA TOMENTOSA L.
• Digitonin-Cholesterol Complex Formation : Effects of Varying the Length of the Side-chain
• INHIBITORS OF PROSTAGLANDIN BIOSYNTHESIS FROM DALBERGIA ODORIFERA
• RADIOIMMUNOASSAY FOR THE DETERMINATION OF GINSENG SAPONIN, GINSENOSIDE RG_1
• Introduction of an Alcoholic Hydroxyl Group into 2,3-Dibenzylbutyrolactone Lignans with Oxidizing Agents and Carbon-13 Nuclear Magnetic Resonance Spectra of the Oxidation Products
• INDUCTION OF DIFFERENTIATION IN MURINE ERYTHROLEUKEMIA CELLS BY FLAVONOIDS
• Biosynthesis of Natural Products. V. Biosynthesis of Itaconitin. (2). Tracer Studies on Itaconitin
• Biosynthesis of Natural Products. IV. Biosynthesis of Itaconitin. (1). Degradation Studies on Itaconitin
• MOLECULAR CLONING OF cDNA ENCODING HUMANLANOSTEROL SYNTHASE
• Production of Polyketide Pigments in Hairy Root Cultures of Cassia Plants
• MOLECULAR CLONING OF cDNA ENCODING RAT 2,3-OXIDOSQUALENE : LANOSTEROL CYCLASE
• FISSOLDHIMINE, A NOVEL SKELETON ALKALOID FROM FISSISTIGMA OLDHAMII
• Post-Aromatic Deoxygenation in Polyketide Biosynthesis : Reduction of Aromatic Rings in the Biosyntheses of Fungal Melanin and Anthraquinone
• Purification and Properties of Squalene-2,3-epoxide Cyclases from Pea Seedlings
• Platelet Activating Factor (PAF) Antagonists Contained in Medicinal Plants : Lignans and Sesquiterpenes
• Inhibition of in Vitro Prostaglandin and Leukotriene Biosyntheses by Cinnamoyl-β-phenethylamine and N-Acyldopamine Derivatives
• Biologically Active Constituents of Melaleuca leucadendron : Inhibitors of Induced Histamine Release from Rat Mast Cells
• Biologically Active Constituents of Centipeda minima : Sesquiterpenes of Potential Anti-allergy Activity
• Biologically Active Constituents of Magnolia salicifolia : Inhibitors of Induced Histamine Release from Rat Mast Cells
• EFFECTS OF SOME PHENOLICS ON THE PROSTAGLAND IN SYNTHESIZING ENZYME SYSTEM
• Formation of Chalcones and Isoflavones by Callus Culture of Glycyrrhiza uralensis with Different Production Patterns
• Inhibitors of Cyclic AMP Phosphodiesterase in Panax ginseng C. A. MEYER and Panax japonicus C. A. MEYER
• Inhibitors of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase in Cassia Seed
• Inhibition of Prostaglandin Biosynthesis by 4-O-Methylcryptochlorophaeic Acid ; : Synthesis of Monomeric Arylcarboxylic Acids for Inhibitory Activity Testing and X-Ray Analysis of 4-O-Methylcryptochlorophaeic Acid
• Hongconin, a New Naphthalene Derivative from Hong-Cong, the Rhizome of Eleutherine ameicana MERR. et HEYNE(Iridaceae)
• STRUCTURES OF PANICULIDINES A AND B : NOVEL PRENYLINDOLES FROM MURRAYA PANICULATA
• Inhibition of Cyclic AMP Phosphodiesterase by Lignans
• PURIFICATION AND SOME PROPERTIES OF SQUALENE-2,3-EPOXIDE : LANOSTEROL CYCLASE FROM RAT LIVER
• PURIFICATION OF 2,3-OXIDOSQUALENE : β-AMYRIN CYCLASE FROM PEA SEEDLINGS
• Inhibitors of Cyclic Adenosine Monophosphate Phosphodiesterase in Polygala tenuifolid
• PURIFICATION AND CHARACTERIZATION OF DIHYDROGEODIN OXIDASE FROM A FUNGAL STRAIN OF ASPERGILLUS TERREUS PRODUCING (+)-GEODIN
• PARTIAL PURIFICATION AND SOME PROPERTIES OF EMODIN-O-METHYLTRANSFERASE FROM (+)-GEODIN PRODUCING STRAIN OF ASPERGILLUS TERREUS
• Biosynthesis of 2-Hexyl-5-propylresorcinol : Biosynthetic Incorporation of Deuterium from [2-^C, 2-^2H_3]-Acetate
• Biologically Active Constituents of Arnebia euchroma : Structures of New Monoterpenylbenzoquinones : Arnebinone and Arnebifuranone
• Biologically Active Constituents of Arnebia euchroma : Structure of Arnebinol, an Ansa-Type Monoterpenylbenzenoid with Inhibitory Activity on Prostaglandin Biosynthesis
• Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Phenolic Constituents of Mulberry Tree
• Inhibitors of Cyclic AMP Phosphodiesterase in Picrasma quassioides BENNET, and Inhibitory Activities of Related β-Carboline Alkaloids
• Inhibitors of Cyclic Adenosine 3', 5'-Monophosphate Phosphodiesterase in Phyllostachys nigra MUNRO var. henonis STAPF. and Phragmites communis TRIN., and Inhibition by Related Compounds
• INHIBITORS OF PROSTAGLANDIN BIOSYNTHESIS FROM ALPINIA OFFICINARUM
• INHIBITORS OF PROSTAGLANDIN BIOSYNTHESIS FROM GINGER
• Synergistic Action of Phenolic Signal Compounds and Carbohydrates in the Induction of Virulence Gene Expression of Agrobacterium tumefaciens
• Identification of Plant Factors Inducing Virulence Gene Expression in Agrobacterium tumefaciens
• HYDROXYACETOSYRINGONE IS THE MAJOR VIRULENCE GENE ACTIVATING FACTOR IN BELLADONNA HAIRY ROOT CULTURES, AND INOSITOL ENHANCES ITS ACTIVITY
• TWO NEW ISOFLAVONOIDS FROM ECHINOSOPHORA KOREENSIS NAKAI AND THE STRUCTURE REVISION OF SOPHORONOL
• DEOXYGENATION IN THE BIOSYNTHESIS OF POLYKETIDES : MECHANISM OF BIOMIMETIC REDUCTION OF TETRAHYDROXYNAPHTHALENE
• ISOFLAVONE SYNTHASE FROM CELL SUSPENSION CULTURES OF PUERARIA LOBATA
• OLIGOSIDE PRODUCTION BY HAIRY ROOT CULTURES TRANSFORMED BY Ri PLASMIDS
• PRODUCTION OF SECONDARY MATABOLITES BY HAIRY ROOTS AND REGENERATED PLANTS TRANSFORMED WITH R1 PLASMIDS
• THE BIOSYNTHESIS OF PATULIN : THE MECHANISM OF OXIDATIVE AROMATIC RING CLEAVAGE AND LOSS OF SIDE CHAIN PROTONS FROM AROMATIC INTERMEDIATES
• BIOLOGICALLY ACTIVE CONSTITUENTS OF CENTIPEDA MINIMA : ISOLATION OF A NEW PLEWOLIN ESTER AND THE ANTIALLERGY ACTIVITY OF SESQUITERPENE LACTONES
• BIOSYNTHESIS OF PATULIN; : IN VITRO CONVERSION OF GENTISYL ALCOHOL INTO PATULIN BY MICROSOMAL ENZYME(S) AND RETENTIOIN OF ONE OF THE CARBINOL PROTONS IN THIS REACTION

もっと見る 閉じる

スポンサーリンク