Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Components of Sophora flavescens AITON

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概要

• 論文の詳細を見る

• Adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase inhibitiors contained in the roots of Sophora flavescens AITON were identified as flavonoids, kushenol A (9), kurarinone (5), and kuraridin (22). The structure-inhibitory activity relationships were studied in 30 flavonoids. O-Methylation of a hydroxyl group on an aromatic ring decreased the activity. The prenyl group is important for high inhibitory activity. A kinetic study revealed that nor-kurarinone, kurarinol and kurafidin non-competitively inhibit cAMP phosphodiesterase.

• 社団法人日本薬学会の論文
• 1986-05-25

著者

• 三川 潮

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 大本 太一

  School of Pharmaceutical Sciences, Toho University

• 呉 立軍

  瀋陽薬学院

• 相川 良介

  School of Pharmaceutical Sciences, Toho University

• 二階堂 保

  School of Pharmaceutical Sciences, Toho University

• 呉 立軍

  Shizuoka College of Pharmacy

• 上野 明

  Shizuoka College of Pharmacy

• 福島 清吾

  Shizuoka College of Pharmacy

• 三川 潮

  Faculty Of Pharmaceuical Sciences The University Of Tokyo

• 福島 清吾

  静岡県立大学薬学部

• 相川 良介

  School Of Pharmaceutical Sciences Toho University

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