Agapanthussaponins A-D, New Potent cAMP Phosphodiesterase Inhibitors from the Underground Parts of Agapanthus inapertus
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概要
- 論文の詳細を見る
The saponin fraction prepared from the methanolic extract of the underground parts of Agapanthus inapertus was found to exhibit inhibitory activity on cAMP phosphodiesterase (55.2%) at a concentration of 100 μg/ml. From this fraction, four new steroidal saponins, designated as agapanthussaponin A (1), B (2), C (3) and D (4), were isolated as the active principles, along with an inactive new furostanol saponin (5). The structures of 1-5 were determined by spectroscopic data and hydrolysis. The IC_<50> of 1-4 on cAMP phosphodiesterase were 0.7,1.2,1.1 and 2.0 (×10^<-5>M), respectively, which are more potent than that of papaverine (IC_<50> 3.0×10^<-5>M).
- 社団法人日本薬学会の論文
- 1993-10-15
著者
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指田 豊
東京薬大・薬・漢方資源応用
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三巻 祥浩
東京薬大・薬・漢方資源応用
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大本 太一
School of Pharmaceutical Sciences, Toho University
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二階堂 保
School of Pharmaceutical Sciences, Toho University
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二階堂 保
東邦大学薬学部
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三巻 祥浩
Tokyo College of Pharmacy
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指田 豊
Tokyo College of Pharmacy
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大本 太一
東邦大薬
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中村 修
School Of Pharmacy Tokyo University Of Pharmacy And Life Science (formerly Tokyo College Of Pharmacy
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中村 修
Tokyo College of Pharmacy
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Mimaki Y
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Satomi Y
National Cancer Center Res. Inst. Tokyo Jpn
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Sashida Y
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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