Relations between the Averaged ^<13>C Nuclear Magnetic Resonance Chemical Shift and the Carcinogenic Activity of Polycyclic Aromatic Hydrocarbons
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概要
- 論文の詳細を見る
^<13>C Nuclear magnetic resonance (^<13>C-NMR) spectra were measured for polycyclic aromatic hydrocarbons (PAH) to examine the correlation between their chemical shift and carcinogenicity. We confirmed our previous proposition that the carcinogenicity of PAH molecules can be predicted from the value of the averaged ^<13>C-NMR chemical shift. It was also found, using the averaged chemical shift as a parameter, that several quantum chemical indices for the intermediate states of the metabolic transformation are correlated with the carcinogenic activity of PAH. This indicates that the averaged chemical shift can be applied to investigate the metabolic transformation of carcinogenicity.
- 社団法人日本薬学会の論文
- 1992-08-25
著者
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坂本 曜子
東邦大学薬学部
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大本 太一
School of Pharmaceutical Sciences, Toho University
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大本 太一
東邦大薬
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大本 太一
Shcool Of Pharmaceutical Sciences Toho University
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坂本 曜子
School of Pharmaceutical Sciences
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大島 茂
Department of Biomolecular Science, Faculty of Science
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大島 茂
東邦大学理学部生物分子科学科
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坂本 曜子
School Of Pharmaceutical Science Toho University
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