セイヨウサンザシ(Crataegus oxyacantha L.)葉の主成分並びに同植物葉及び市販セイヨウサンザシ葉製品の分析

概要

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The leaves of hawthorn (Crataegus oxyacantha L.) has been classified in the raw materials exclusively used as pharmaceuticals in Japan. In the course of our continuous studies for identification of secondary metabolites of the raw materials exclusively used as pharmaceuticals, we isolated three main components (A〜C) and two minor components (D, E) from the methanol extract. Each component was identified as 3-O-caffeoylquinic acid (A), vitexin 2"-α-L-rhamnoside (B), vitexin 2"-(4-O-acetyl-α-L-rhamnoside) (C),9-O-β-D-glucopyranosyl-4, 9-dihydroxy-3-methoxypropiophenone (D) and 4-O-β-D-glucopyranosyl-p-coumaric acid (E) by using NMR and LC-MS techniques. In addition, we did not detect any alkaloid-like spot on the thin layer chromatography of the extract with the Dragendorff reagent. Next, we performed HPLC analyses of the commercial hawthorn leave products obtained in European markets. The main components of the products are the same of the methanol extracts of the leaves and the HPLC profiles are similar to that of the leaves. This suggests that the species used for the European hawthorn leave products are that closely related to C. oxyacantha L.
日本食品化学学会の論文
2007-08-31