On the relationship between the chemical structure and the cyclic AMP phosphodiesterase inhibitory activity of flavonoids as studied by 13CNMR.
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概要
- 論文の詳細を見る
The relationship between the chemical structure and the cyclic adenosine monophosphate phosphodiesterase inhibitory activity was studied regarding forty-eight flavones, thirty-five flavanones, and six isoflavones by using the <SUP>13</SUP>C NMR chemical shift averaged over all aromatic carbons in a compound. The average value of potent <SUP>13</SUP>C chemical shifts over the aromatic carbons active flavonoids (IC<SUB>50</SUB> 0.6–20.0×10<SUP>−5</SUP> M/L) are within the range from δ 133.5 to δ 135.7, but those of the inactive flavonoids and the weak active flavonoids are not within this range. This means that the averaged <SUP>13</SUP>C chemical shift becomes an "index" for testing the inhibitory activity. Further, the above relationship was proposed as a means for conveniently determining the inhibitory activity.
- 公益社団法人 日本化学会の論文
著者
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Yokoe Ichiro
Faculty of Pharmaceutical Science, Josai University
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Miyaichi Yukinori
School Of Pharmacy Hokuriku University
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Ando Isao
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Tomimori Tsuyoshi
School Of Pharmacy Hokuriku University
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OHMOTO TAICHI
School of Pharmaceutical Science, Toho University
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NIKAIDO TAMOTSU
School of Pharmaceutical Science, Toho University
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KOIKE KAZUO
School of Pharmaceutical Science, Toho University
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Sakamoto Yohko
School of Pharmaceutical Science, Toho University
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Yokoe Ichiro
Faculty of Pharmaceutical Sciences, Josai University
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Shirataki Yoshiaki
School of Pharmacy, Hokuriku University
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Monache F.
Centro Chimica dei Recettori del C. N. R., Universita Cattolica
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Botta B.
Centro Chimica dei Recettori del C. N. R., Universita Cattolica
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Komatsu Manki
Faculty of Pharmaceutical Sciences, Josai University
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Watanabe Shosuke
Nihon Junior College of Economics
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Sakamoto Yohko
School of Pharmaceutical Sciences, Toho University
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