Picrodendrins, a New Group of Picrotoxane Terpenoids : Structur-Activity Profile of Action at the GABA_A Receptor-coupled Picrotoxinin Binding Site in Rat Brain
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概要
- 論文の詳細を見る
Seven out of 20 assayed picrotoxane terpenoids inhibited specific binding of [^<35>S] t-butylbicyclophosphorothionate to rat brain membranes, with IC_<50> values of 0. 0075-6. 0μM. Picrodendrin Q was identified as the most potent compound, being about 27-fold more potent than picrotoxinin. The high activity of picrodendrins A, M, and Q suggests the significance of the spiro α-ethylidene γ-lactone moiety for the interaction of picrodendrins with the GABAA receptor-coupled picrotoxinin binding site.
- 社団法人日本農芸化学会の論文
- 1994-08-23
著者
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KOIKE Kazuo
School of Pharmaceutical Sciences, Toho University
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OHMOTO Taichi
School of Pharmaceutical Sciences, Toho University
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Koike Kazuo
School Of Pharmaceutical Sciences Toho University
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SUZUKI Yumiko
School of Pharmaceutical Sciences, University of Shizuoka
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Ohmoto T
Environmental Technol. Res. Div. Osaka Municipal Technical Res. Inst.
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HIRATA Hajime
Department of Life Science, Himeji Institute of Technology
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Suzuki Yumiko
School Of Pharmaceutical Sciences University Of Shizuoka
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Ohe Tatsuhiko
Department Of Environmental Technology Osaka Municipal Technical Research Institute
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Mochida K
Kyowa Hakko Kogyo Co. Ltd. Tokyo Jpn
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Ohmoto Taichi
Faculty Of Pharmaceutical Sciences Toho University
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Ozoe Y
Shimane Univ. Shimane Jpn
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Hasegawa Hiroko
Department Of Life Science Himeji Institute Of Technology
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Ozoe Yoshihisa
Faculty of Agriculture, Shimane University
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Hasegawa Hiroko
Faculty of Agriculture, Shimane University
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Mochida Kazuo
Faculty of Agriculture, Shimane University
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Nagahisa Masako
School of Pharmaceutical Sciences, Toho University
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Ohmoto Taichi
School Of Pharmaceutical Sciences Toho University
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Mochida Kazuo
Department Of Life Science And Biotechnology Faculty Of Life And Environmental Science Shimane Unive
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Nagahisa Masako
School Of Pharmaceutical Sciences Toho University
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Suzuki Yumiko
School Of Pharmaceutical Sciences Toho University
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Ohmoto Taichi
Environmental Technology Research Division Osaka Municipal Technical Research Institute
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OHMOTO TAICHI
School of Pharmaceutical Science, Toho University
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KOIKE KAZUO
School of Pharmaceutical Science, Toho University
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