Synthesis of Heterocyclic Compounds via Nucleophilic Aroylation Catalyzed by Imidazolidenyl Carbene
スポンサーリンク
概要
- 論文の詳細を見る
Xanthones and acridones were synthesized from 3, 4-difluoronitrobenzene and 2-fluorobenzaldehydes in two or three steps. The key step was nucleophilic aroylation catalyzed by imidazolidenyl carbene. The nucleophilic aroylation of 3, 4-difluoronitrobenzene afforded 2, 2'-difluoro-4-nitrobenzophenones. The cyclization of the difluorobenzophenones with O-nucleophile and N-nucleophile yielded 3-nitroxanthones and 3-nitroacridones, respectively. Indazole, quinolino [2, 3-b] quinoxaline, and thianaphtho [2, 3-b] quinoxaline derivatives were also synthesized via nucleophilic aroylation of 2, 3-dichloroquinoxaline followed by cyclization with nucleophiles.
- 公益社団法人日本薬学会の論文
- 2006-12-01
著者
-
MIYASHITA Akira
School of Pharmaceutical Sciences, University of Shizuoka
-
SATO Masayuki
School of Pharmaceutical Sciences, University of Shizuoka
-
Suzuki Yumiko
School Of Pharmaceutical Sciences University Of Shizuoka
-
Miyashita Akira
School Of Pharmaceutical Sciences University Of Shizuoka
-
TOYOTA Tomonori
School of Pharmaceutical Sciences, University of Shizuoka
-
Toyota Tomonori
School Of Pharmaceutical Sciences University Of Shizuoka
-
Suzuki Yumiko
School Of Pharmaceutical Sciences Toho University
-
Sato Masayuki
School Of Pharmaceutical Sciences University Of Shizuoka
-
Sato Masayuki
School Of Pharmaceutical Sciences Univ. Of Shizuoka
-
Suzuki Yumiko
School Of Pharmaceutical Sciences Univ. Of Shizuoka
関連論文
- Catalytic Action of Azolium Salts. IX. Synthesis of 6-Aroyl-9H-purines and Their Analogues by Nucleophilic Aroylation Catalyzed by Imidazolium or Benzimidazolium Salt
- Carbon-Carbon Bond Cleavage of α-Hydroxybenzylheteroarenes Catalyzed by Cyanide Ion : Retro-Benzoin Condensation Affords Ketones and Heteroarenes and Benzyl Migration Affords Benzylheteroarenes and Arenecarbaldehydes
- Carbon-Carbon Bond Cleavage of α-Substituted Benzoins by Retro-Benzoin Condensation : A New Method of Synthesizing Ketones
- Catalytic Action of Azolium Salts. VIII. Oxidative Aroylation with Arenecarbaldehydes Catalyzed by 1,3-Dimethylbenzimidazolium Iodide
- A New Method of Synthesizing Deoxybenzoins from 1,3-Dimethyl-2-(α-benzyloxybenzyl)imidazolium and 1,3-Dimethyl-2-(α-benzyloxybenzyl)benzimidazolium Iodides Based on Wittig-Type Rearrangement
- Olefin-Insertion Reaction between the Carbonyls of Benzils ; Formation of 1, 4-Diketons by Michael Addition Catalyzed by Cyanide Ion
- SYNTHESIS OF KETONES BY RETRO-BENZOIN CONDENSATION CATALYZED BY POTASSIUM CYANIDE
- Synthesis and Biological Evaluation of Peptide Mimics Derived from First Extracellular Loop of CCR5 toward HIV-1
- SYNTHESIS OF 1,4-DIKETONES BY MICHAEL ADDITION OF O-AROYLMANDELO-NITRILES INVOLVING REARRANGEMENT OF AROYL GROUP AND DECYANATION
- Recognition of Planar Chirality by Cyclodextrins
- Picrodendrins, a New Group of Picrotoxane Terpenoids : Structur-Activity Profile of Action at the GABA_A Receptor-coupled Picrotoxinin Binding Site in Rat Brain
- Synthesis of Heterocyclic Compounds via Nucleophilic Aroylation Catalyzed by Imidazolidenyl Carbene
- Rh-N-Heterocyclic Carbene (NHC) Complex-Catalyzed Addition of Phenylboronic Acid to N-Sulfonyl and N-Phosphinoyl Aldimines
- N-Heterocyclic Carbene Ligands in Copper-Catalyzed Addition of Diethylzinc to N-Sulfonylimines
- Preparation of 4-Pentenoic Acid Ester of Neu5Ac and 4-Pentenyl Glycoside of Neu5Ac and Their Application to Glycosylation