Cycloprodigiosin Hydrochloride Obtained from Pseudoalteromonas denitrificans Is a Potent Antimalarial Agent
スポンサーリンク
概要
- 論文の詳細を見る
Cycloprodigiosin hydrochloride (cPrG・HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent.The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG・HCl was also observed in vivo. These results indicate that cPrG・HCl is a potent antimalarial drug.
- 公益社団法人日本薬学会の論文
- 1999-05-15
著者
-
柴田 芳宏
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
-
Kim Hye-sook
岡山大学 薬学部
-
Tsuboi Seiji
Biochemistry Faculty Of Pharmaceutical Sciences Okayama University
-
WATAYA Yusuke
Department of Medicinal Information, Faculty of Pharmaceutical Science, Okayama University
-
Kim Hee-sung
Department Of Pharmacology College Of Medicine Institute Of Natural Medicine Hallym University
-
HIRATA Hajime
Department of Life Science, Himeji Institute of Technology
-
Horii Toshihiro
Research Institute For Microbial Diseases Osaka University
-
Moriyama Yoshinori
Mukaishima Marine Biological Laboratory Faculty Of Science And Laboratory Of Marine Molecular Biolog
-
Moriyama Yoshinori
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)
-
Moriyama Yoshinori
Marine Biological Laboratory Graduate Department Of Gene Science Faculty Of Sciences Hiroshima Unive
-
KIM Hye-Sook
Department of Pharmaceutical Information Science, Faculty of Pharmaceutical Sciences, Okayama Univer
-
HAYASHI Mitsuko
Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University
-
SHIBATA Yasuharu
Departments of Pharmaceutical Information Science Faculty of pharmaceutical Sciences, Okayama Univer
-
MITAMURA Toshihide
Research Institute for Microbial Diseases, Osaka University
-
KAWAUCHI Keiko
Department of Life Science, Faculty of Science, Himeji Institute of Technology
-
MORIYAMA Yoshinori
Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University
-
Hirata Hajime
Department Of Life Science Faculty Of Science Hyogo University
-
Wataya Y
Faculty Of Pharmaceutical Sciences Okayama University
-
Wataya Yusuke
Fac. Of Pharmaceutical Sci. Graduate School Of Medicine Dentistry And Pharmaceutical Sci. Okayama Un
-
Wataya Yusuke
Department Of Medicinal Information Faculty Of Pharmaceutical Science Okayama University
-
Hayashi Mitsuko
Biochemistry Faculty Of Pharmaceutical Sciences Okayama University
-
Shibata Y
Environmental Chemistry Division National Institute For Environmental Studies
-
Moriyama Y
Department Of Membrane Biochemistry Okayama University Graduate School Of Medicine Dentistry And Pha
-
Hirata H
Department Of Life Science Graduate School Of Science Himeji Institute Of Technology
-
Kawauchi Keiko
Department Of Molecular Oncology Institute Of Gerontology Nippon Medical School
-
Kim H‐s
Okayama Univ. Okayama Jpn
-
Kaneshiro Keiko
Department Of Life Science Faculty Of Science Hyogo University
関連論文
- Benzylphthalimides and Phenethylphthalimides with Thalidomide-Like Activity on the Production of Tumor Necrosis Factor α
- N-ALKYLPHTHALIMIDES : STRUCTURAL REQUIREMENT OF THALIDOMIDAL ACTION ON 12-0-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED TUMOR NECROSIS FACTOR α PRODUCTION BY HUMAN LEUKEMIA HL-60 CELLS
- ENHANCEMENT OF PHORBOL ESTER-INDUCED PRODUCTION OF TUMOR NECROSIS FACTOR-α BY 2,6-DIMETHYLPHENYLPHTHALIMIDE
- ENHANCEMENT OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED TUMOR NECROSIS FACTOR α PRODUCTION BY PHENETHYLPHTHALIMIDE ANALOGS
- Identification of the four species of human malaria parasites by nested PCR that targets variant sequences in the small subunit rRNA gene
- Antimalarial Activity of Herbal Extracts Used in Traditional Medicine in Korea(Pharmacognosy)
- Inhibitory Effects of Long-Term Administration of Ferulic Acid on Microglial Activation Induced by Intracerebroventricular Injection of β-Amyloid Peptide (1-42) in Mice(Pharmacology)
- Synthesis and Biological Activity of Fatty Acid Derivatives of Quinine
- MEMBRANOUS ATPASES AND TRANSPORT FUNCTIONS OF LYSOSOMES (Functional Morphology and Pathology of Lysosomes)
- Synthesis and Evaluation of β-Carbolinium Cations as New Antimalarial Agents Based on π-Delocalized Lipophilic Cation (DLC) Hypothesis
- Antimalarial and Cytotoxic Activities of Bicyclo[6. 4. 0]dodecenones
- Characterization of Murine Grancalcin Specifically Expressed in Leukocytes and Its Possible Role in Host Defense against Bacterial Infection
- Preparation and Characterization of Recombinant Murine p65/L-Plastin Expressed in Escherichia coli and High-titer Antibodies against the Protein(Biochemistry & Molecular Biology)
- A potent antimalarial activity of 5-fluoroorotate in combination with sulfamonomethoxine against Plasmodium falciparum in vitro and Plasmodium berghei in mice
- Potent in vivo antimalarial activity of 3.15-di-O-acetybruceolide against Plasmodium berghei infection in mice
- Cycloprodigiosin Hydrochloride Obtained from Pseudoalteromonas denitrificans Is a Potent Antimalarial Agent
- CASES OF OVALE MALARIA AND MALARIAE MALARIA SUCCESSFULLY TREATED WITH MEFLOQUINE
- AUGMENTATION BY PHTHALIMIDES OF PHORBOL ESTER-INDUCED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHA MESSAGE
- Phenylphthalimides with Tumor Necrosis Factor Alpha Production-Enhancing Activity
- Analysis of a Bacterial Lipopolysaccharide-Activated Serine Kinase That Phosphorylates p65/L-Plastin in Macrophages
- Suppression of AP-1 Activity by Cycloprodigiosin Hydrochloride(Molecular and Cell Biology)
- Immunoreactivity of Vacuolar H^+-ATPase in Human Tissues : Using Polyclonal Rabbit Antibodies against V-ATPase Subunits
- Cycloprodigiosin Uncouples H^+-Pyrophosphatase of Plant Vacuolar Membranes in the Presence of Chloride Ion
- CYCLOPRODIGIOSIN UNCOUPLES VACUOLAR H^+-PYROPHOSPHATASE IN THE PRESENCE OF Cl^-
- Synthesis of New Fused Pyrimidines by Isocyanate and Isothiocyanate
- Concanamycin B Inhibits the Expression of Newly-synthesized MHC Class II Molecules on the Cell Surface
- Antimalarial Activity of Lavandulyl Flavanones Isolated from the Roots of Sophora flavescens (Pharmacognosy)
- Bafilomycin A_1 Prevents Maturation of Autophagic Vacuoles by Inhibiting Fusion between Autophagosomes and Lysosomes in Rat Hepatoma Cell Line, H-4-II-E Cells
- Acridine Orange as a Fluorescent Probe for Lysosomal Proton Pump
- Possible Remediation of Dioxin-Polluted Soil by Steam Distillation
- Exocytosis of D-Aspartate from INS-1E Clonal β Cells(Biochemistry)
- Involvement of Vesicular H^+-ATPase in Insulin-Stimulated Glucose Transport in 3T3-F442A Adipocytes
- Specific Increase in the Number of Vanadium-Containing Blood Cells by Some Ionophores and Inhibitors of Proton-ATPases in the Ascidian, Ascidia sydneiensis samea
- Finding of the Same Antigens in the Polychaete, Pseudopotamilla occelata, as Those in the Vanadium-Rich Ascidian, Ascidia sydneiensis samea
- Identification of a Vanadium-Associated Protein from the Vanadium-Rich Ascidian, Ascidia sydneiensis samea
- Localization, with Monoclonal Antibodies and by Detection of Autonomous Fluorescence, of Blood Cells in the Tissues of the Vanadium-Rich Ascidian, Ascidia sydneiensis samea
- LYSOSOMAL H^+- ADENOSINE TRIPHOSPHATASE IS SIMILAR TO MITOCHONDRIAL H^+- ADENOSINE TRIPHOSPHATASE IN ITS SENSITIVITY TO DRUGS AND ANIONS AFTER SOLUBILIZATION
- Sesquilignan Haedoxans : Interaction with the GABA_A Receptor in Rat Brain
- A Novel Neutral Amino Acid Transporter from the Hyperthermophilic Archaeon Thermococcus sp. KS-1
- Overexpression of the Alanine Carrier Protein Gene from Thermophilic Bacterium PS3 in Escherichia coli
- Picrodendrins, a New Group of Picrotoxane Terpenoids : Structur-Activity Profile of Action at the GABA_A Receptor-coupled Picrotoxinin Binding Site in Rat Brain
- Synthesis of Novel Conjugates of Tetraoxane Endoperoxide with Bis (Quaternary Ammonium Salts)
- Demonstration of CL^-Requirement for Inhibition of Vacuolar Acidification by Cycloprodigiosin in Situ
- Vesicular Glutamate Transporter Acts as a Metabolic Regulator(Physiology and Pharmacology of the Gut Nutrient Perception)
- Glutamatergic Chemical Transmission : Look! Here, There, and Anywhere
- Cycloprodigiosin Hydrochloride Activates the Ras-PI3K-Akt Pathway and Suppresses Protein Synthesis Inhibition-Induced Apoptosis in PC12 Cells
- Foreword(Physiology and Pharmacology of the Gut Nutrient Perception)
- Three-dimensional finite strain analysis in the high-grade part of the Sanbagawa Belt using deformed meta-conglomerate
- Cycloprodigiosin Hydrochloride Inhibits Acidification of the Plant Vacuole
- A Vesicular Transporter That Mediates Aspartate and Glutamate Neurotransmission
- Riboflavin transporter is finally identified
- A Novel Neutral Amino Acid Transporter from the Hyperthermophilic Archaeon Thermococcus sp. KS-1.
- Floating-gate type organic memory device with organic insulator film of plasma polymerized styrene