Vesicular Glutamate Transporter Acts as a Metabolic Regulator(Physiology and Pharmacology of the Gut Nutrient Perception)
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概要
- 論文の詳細を見る
Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate into synaptic vesicles and, thus, plays an essential role in the glutamatergic chemical transmission in the central and peripheral nervous systems. Recent studies indicated that VGLUT is also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells. L-Glutamate is stored in VGLUT-containing organelles, secreted upon stimulation, and then acts as a paracrine and/or autocrine modulator to regulate cellular functions. Thus, VGLUT is a key molecule for glutamate signaling and is the core of a novel signaling system.
- 公益社団法人日本薬学会の論文
- 2008-10-01
著者
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MORIYAMA YOSHINORI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kanazawa University
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Moriyama Yoshinori
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)
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Omote Hiroshi
Department Of Membrane Biochemistry Okayama University Graduate School Of Medicine Dentistry And Pha
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Moriyama Yoshinori
Department Of Membrane Biochemistry Okayama University Graduate School Of Medicine Dentistry And Pha
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Omote Hiroshi
Department Of Mechanical And Physical Engineering Graduate School Of Engineering Osaka City University:research & Development Center Yanmar Co. Ltd.
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