MEMBRANOUS ATPASES AND TRANSPORT FUNCTIONS OF LYSOSOMES (<Symposium>Functional Morphology and Pathology of Lysosomes)
スポンサーリンク
概要
- 論文の詳細を見る
A conspicuous feature of lysosomes is that their interior is acidic providing favorable conditions for acid hydrolases therein. Its precise pH as well as its maintenance mechanism have long been a matter of dispute. We estimated the intralysosomal pH using fluorescein isothiocyanate-dextran (FITC-dextran, FD) fluorescence to be slightly lower than 5.0 and showed that it is maintained using metabolic energy. We also showed that the intralysosomal acidity is raised by exposure of cells to weak basic substances or acidic ionophores. These findings have attracted attention from a variety of fields, because these chemicals have been known to affect a variety of biologically important phenomena. The interest in the physiological significance of this phenomenon has been strenghthened furthermore by the recent discovery of additional acidic pockets, namely, endosomes, Golgi apparatus, secretory granules, kidney plasmalemmal vesicles, etc.
- 日本組織細胞化学会の論文
著者
-
ARAI Kunizo
Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University
-
Arai K
Kanazawa Univ. Ishikawa Jpn
-
Arai Kunizo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University
-
WATANABE Hirokazu
Department of Dermatology, Graduate School of Medicine, University of Toyama
-
HAYASHI Hidetoshi
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences
-
Hayashi Hidetoshi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University
-
OHKUMA SHOJI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kanazawa University
-
MORIYAMA YOSHINORI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kanazawa University
-
IINUMA KIYOHISA
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kanazawa University
-
MORIMOTO YOSHINOBU
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kanazawa University
-
SHIMIZU SAKAE
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kanazawa University
-
Moriyama Yoshinori
Mukaishima Marine Biological Laboratory Faculty Of Science And Laboratory Of Marine Molecular Biolog
-
Moriyama Yoshinori
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)
-
Moriyama Yoshinori
Marine Biological Laboratory Graduate Department Of Gene Science Faculty Of Sciences Hiroshima Unive
-
Ohkuma S
Kanazawa Univ. Ishikawa Jpn
-
Ohkuma Shoji
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University
-
Shimizu Sakae
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University
-
Iinuma Kiyohisa
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)
-
Watanabe Hirokazu
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)
-
Watanabe Hidenobu
Department Of Pathology Niigata University School Of Medicine
-
Watanabe Hirokazu
Department Of Applied Chemistry Nagoya Institute Of Technology
関連論文
- Dual Mode of Regulation of Cell Division Cycle 25 A Protein by TRB3
- Axonal Regeneration of Fish Optic Nerve after Injury
- Changes in NADPH diaphorase expression in the fish visual system during optic nerve regeneration and retinal development
- p21^ and Ki-67 Expression of Serrated Adenoma of the Colorectum : An Investigation of Cell Differentiation/Maturation and its Relationship with Cell Proliferation
- Proliferation kinetics and apoptosis of serrated adenoma of the colorectum
- P4-13 Correlation between Immunohistochemical Cell Kinetics and Macroscopic Phenotype of Colorectal Serrated Adenoma
- Macrophage migration inhibitory factor (MIF) in bullous pemphigoid
- Interleukin-1β and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression
- Gene Expression Profiling Identifies a Role for CHOP During Inhibition of the Mitochondrial Respiratory Chain
- Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients
- Dihydrotestosterone Inhibits Tumor Necrosis Factor α Induced Interleukin-1α mRNA Expression in Rheumatoid Fibroblast-Like Synovial Cells(Molecular and Cell Biology)
- Novel mutation in a fumalate hydratase gene of a Japanese patient with multiple cutaneous and uterine leiomyomatosis
- Tumor response to chemotherapy : The validity and reproducibility of RECIST guidelines in NSCLC patients
- MEMBRANOUS ATPASES AND TRANSPORT FUNCTIONS OF LYSOSOMES (Functional Morphology and Pathology of Lysosomes)
- ARF-Induced Lysosomal Lysis In Vitro^1
- Disintegration of lysosomes mediated by GTP γS-treated cytosol: Possible involvement of phospholipases
- A Comparative Study of (Ca^-Mg^)-ATPase on the Lysosomal Membrane and ecto-ATPase on the Plasma Membrane from Rat Liver
- Properties of H^+-ATPase from Rat Liver Lysosomes as Revealed by Reconstitution into Proteoliposomes
- Evaluation of Selective Competitive Binding of Basic Drugs to α1-Acid Glycoprotein Variants
- ATP-dependent Lysis of Isolated Lysosomes by Basic Substances and Acidic Ionophores
- INVOLVEMENT OF MACROPHAGES IN ACCUMULATION AND ELIMINATION OF CHOLESTEROL ESTER IN ATHEROSCLEROTIC AORTA (Cytochemistry of Macrophage)
- Cycloprodigiosin Hydrochloride Obtained from Pseudoalteromonas denitrificans Is a Potent Antimalarial Agent
- Polycyclic Aromatic Hydrocarbon Increases mRNA Level for Interleukin 1 Beta in Human Fibroblast-Like Synoviocyte Line via Aryl Hydrocarbon Receptor (Analytical Biochemistry)
- Identification of a Novel Growth-Promoting Factor with a Wide Target Cell Spectrum from Various Tumor Cells as Catalase
- Transfection of Human Melanoma Cells with Type I Interleukin-1 (IL-1) Receptor cDNA Rendered Them IL-1-Responsive and Revealed the Importance of ODC Activity Down-Regulation in IL-1-Induced Growth Inhibition
- Cell-Cycle-Dependent Regulation of Ca^-Activated K^+ Channel in Jurkat T-Lymphocyte
- Suppression of AP-1 Activity by Cycloprodigiosin Hydrochloride(Molecular and Cell Biology)
- Desmoplastic fibroblastoma (collagenous fibroma)
- Immunoreactivity of Vacuolar H^+-ATPase in Human Tissues : Using Polyclonal Rabbit Antibodies against V-ATPase Subunits
- Concanamycin B Inhibits the Expression of Newly-synthesized MHC Class II Molecules on the Cell Surface
- 3-Methylcholanthrene Activates Human Immunodeficiency Virus Type 1 Replication via Aryl Hydrocarbon Receptor
- Bafilomycin A_1 Prevents Maturation of Autophagic Vacuoles by Inhibiting Fusion between Autophagosomes and Lysosomes in Rat Hepatoma Cell Line, H-4-II-E Cells
- Acridine Orange as a Fluorescent Probe for Lysosomal Proton Pump
- Giant cystic basal cell carcinoma mimicking epidermal cyst
- Keishibukuryogan (Gui-Zhi-Fu-Ling-Wan), a Kampo formula decreases the disease activity and the level of serum thymus and activation-regulated chemokine (TARC) in patients with atopic dermatitis
- Uptake of Basic Drugs into Rat Lung Granule Fraction in Vitro
- Characteristic Subcellular Distribution, in Brain, Heart and Lung, of Biperiden, Trihexyphenidyl, and (-)-Quinuclidinyl Benzylate in Rats
- Exocytosis of D-Aspartate from INS-1E Clonal β Cells(Biochemistry)
- Involvement of Vesicular H^+-ATPase in Insulin-Stimulated Glucose Transport in 3T3-F442A Adipocytes
- Small GTP-Binding Proteins on Rat Liver Lysosomal Membranes
- CINEMICROPHOTOGRAPHIC OBSERVATION OF AORTIC FOAM CELLS CONTAINING ANISOTROPIC LIPID INCLUSIONS
- Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells
- Clear cell chondrosarcomas arising from rare sites
- CHRONOPHARMACOKINETIC ASPECTS OF DRUG ACTION
- Specific Increase in the Number of Vanadium-Containing Blood Cells by Some Ionophores and Inhibitors of Proton-ATPases in the Ascidian, Ascidia sydneiensis samea
- Finding of the Same Antigens in the Polychaete, Pseudopotamilla occelata, as Those in the Vanadium-Rich Ascidian, Ascidia sydneiensis samea
- Identification of a Vanadium-Associated Protein from the Vanadium-Rich Ascidian, Ascidia sydneiensis samea
- Localization, with Monoclonal Antibodies and by Detection of Autonomous Fluorescence, of Blood Cells in the Tissues of the Vanadium-Rich Ascidian, Ascidia sydneiensis samea
- LYSOSOMAL H^+- ADENOSINE TRIPHOSPHATASE IS SIMILAR TO MITOCHONDRIAL H^+- ADENOSINE TRIPHOSPHATASE IN ITS SENSITIVITY TO DRUGS AND ANIONS AFTER SOLUBILIZATION
- A case of early lung cancer followed for 5 years and 7 months on chest CT/HRCT
- Retreatment of recurrent malignant pleural mesothelioma with cisplatin and pemetrexed
- Localized Malignant Pleural Mesothelioma Showing a Thoracic Mass and Metastasizing to the Stomach
- Chronotoxicity of Sodium Valproate in Pregnant Mouse and Embryo
- 高強度白金黒電解析出法を用いたマイクログルコ-スセンサの開発〔英文〕 (バイオエレクトロケミストリ-の新展開)
- Vesicular Glutamate Transporter Acts as a Metabolic Regulator(Physiology and Pharmacology of the Gut Nutrient Perception)
- Glutamatergic Chemical Transmission : Look! Here, There, and Anywhere
- Cycloprodigiosin Hydrochloride Activates the Ras-PI3K-Akt Pathway and Suppresses Protein Synthesis Inhibition-Induced Apoptosis in PC12 Cells
- Foreword(Physiology and Pharmacology of the Gut Nutrient Perception)
- Three-dimensional finite strain analysis in the high-grade part of the Sanbagawa Belt using deformed meta-conglomerate
- Successful treatment of gallbladder carcinoma producing alpha-fetoprotein with segmental adenomyomatosis
- A Vesicular Transporter That Mediates Aspartate and Glutamate Neurotransmission
- Ossifying fibromyxoid tumor of the retroperitoneum
- Biphasic intra-abdominal desmoplastic small cell tumor in a patient with proximal spinal muscular atrophy
- Histamine Release Induced by Immobilization, Gentle Handling and Decapitation From Mast Cells and Its Inhibition by Nedocromil in Rats
- Dihydrotestosterone Inhibits Interleukin-1α or Tumor Necrosis Factor α-Induced Proinflammatory Cytokine Production via Androgen Receptor-Dependent Inhibition of Nuclear Factor-κB Activation in Rheumatoid Fibroblast-Like Synovial Cell Line
- Differential Effects of Prostaglandin E_1 and Prostaglandin E_2 on Growth and Differentiation of Murine Myeloid Leukemic Cell Line, M1
- High-dose dexamethasone plus antihistamine prevents colorectal cancer patients treated with modified FOLFOX6 from hypersensitivity reactions induced by oxaliplatin
- Riboflavin transporter is finally identified
- Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate
- Influence of cimetidine on the kinetics of diazepam and lorazepam.
- Morphological Characteristics of Human Extrahepatic Bile Duct Carcinoma
- Phase II study of bi-weekly irinotecan for patients with previously treated HER2-negative metastatic breast cancer : KMBOG0610B