Axonal Regeneration of Fish Optic Nerve after Injury

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概要

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• Since Sperry's work in the 1950s, it has been known that the central nervous system (CNS) neurons of lower vertebrates such as fish and amphibians can regenerate after axotomy, whereas the CNS neurons of mammals become apoptotic after axotomy. The goldfish optic nerve (ON) is one of the most studied animal models of CNS regeneration. Morphological changes in the goldfish retina and tectum after ON transection were first researched in the 1970s-1980s. Many biochemical studies of neurite outgrowth-promoting substances were then carried out in the 1980s-1990s. Many factors have been reported to be active substances that show increased levels during fish ON regeneration, as shown by using various protein chemistry techniques. However, there are very few molecular cloning techniques for studying ON regeneration after injury. In this review article, we summarize the neurite outgrowth-promoting factors reported by other researchers and describe our strategies for searching for ON regenerating molecules using a differential hybridization technique in the goldfish visual system. The process of goldfish ON regeneration after injury is very long. It takes about half a year from the start of axonal regrowth to complete restoration of vision. The process has been classified into three stages : early, middle and late. We screened for genes with increased expression during regeneration using axotomized goldfish retinal and tectal cDNA libraries and obtained stage-specific cDNA clones that were upregulated in the retina and tectum. We further discuss functional roles of these molecules in the regeneration processes of goldfish ON.

• 社団法人日本薬学会の論文
• 2004-04-01

著者

• Kato Satoru

  Department Of Neurophysiology Neuroinformation Research Institute University Of Kanazawa School Of M

• Koriyama Yoshiki

  Kanazawa Univ. Kanazawa Jpn

• Koriyama Yoshiki

  金沢大学 小児科学

• Koriyama Yoshiki

  Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University

• Koriyama Yoshiki

  Department Of Molecular Neurobiology Kanazawa University School Of Medicine

• Kato Satoru

  Kanazawa Univ. Kanazawa Jpn

• MATSUKAWA Toru

  Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University

• ARAI Kunizo

  Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University

• LIU Zhongwu

  Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University

• Arai Kunizo

  Department Of Molecular Neurobiology Graduate School Of Medicine Kanazawa University:laboratory Of M

• Arai Kunizo

  金沢大学 医系研究 分子神経情報

• 賀登 志朗

  大日本製薬株式会社創薬研究所

• Liu Z

  Department Of Molecular Neurobiology Graduate School Of Medicine Kanazawa University

• Arai Kunizo

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University

• Kato S

  Discovery Research Laboratories I Dainippon Pharmaceutical Co. Ltd.

• Kato S

  Chemistry Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• Kato Satoru

  Department Of Molecular Neurobiology Graduate School Of Medicine Kanazawa University:crest

• Matsukawa Toru

  Department Of Molecular Neurobiology Graduate School Of Medicine Kanazawa University:crest

• Liu Zhong

  Department Of Molecular Neurobiology Graduate School Of Medicine University Of Kanazawa

• Liu Zhongwu

  Department Of Molecular Neurobiology Graduate School Of Medicine Kanazawa University

• Kato Satoru

  Department Of Applied Chemistry Graduate School Of Engineering Nagoya University

• Kato Satoru

  Department Of Molecular Neurobiology Graduate School Of Medicine University Of Kanazawa

• Matsukawa Toru

  Department Of Molecular Neurobiology Graduate School Of Medicine University Of Kanazawa

• Kato Satoru

  Department of agriculture, Kinki University

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