Neuritogenic Activity of Trichostatin A in Adult Rat Retinal Ganglion Cells Through Acetylation of Histone H3 Lysine 9 and RARβ Induction
スポンサーリンク
概要
- 論文の詳細を見る
Like other CNS neurons, mature retinal ganglion cells (RGCs) cannot regenerate their axons after nerve injury due to loss of regenerative capacity. One of the reasons why they lose their capacity seems to be a dramatic shift in gene expression of RGCs under epigenetic modulation. In here, we found that levels of histone H3 lysine 9 acetylation decreased after birth in RGCs. This decrease showed good correlation with restriction of retinoic acid receptor β (RARβ) expression in RGCs after birth. Furthermore, we demonstrated that a histone deacetylase inhibitor, trichostatin A, induced axonal regeneration of adult rat RGCs through RARβ induction.
- 公益社団法人 日本薬理学会の論文
著者
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Koriyama Yoshiki
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
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Kato Satoru
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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Ogai Kazuhiro
Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University, Japan
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Sugitani Kayo
Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Japan
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Kato Satoru
Department of agriculture, Kinki University
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