Comparative study of novel ultradeformable liposomes: menthosomes, transfersomes and liposomes for enhancing skin permeation of meloxicam
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概要
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In the present study, novel ultradeformable liposomes (menthosomes; MTS), deformable liposomes (transfersomes; TFS) and conventional liposomes (CLP) were compared in their potential for transdermal delivery of meloxicam (MX). MTS, TFS and CLP were investigated for size, size distribution, zeta potential, elasticity, entrapment efficiency and stability. In vitro skin permeation using hairless mice skin was evaluated. Vesicular morphology was observed under freeze-fractured transmission electron microscopy (FF-TEM). Intrinsic thermal properties were performed using differential scanning calorimetry (DSC) and X-ray diffraction. The skin permeation mechanism was characterized using confocal laser scanning microscopy (CLSM). The results indicated that the difference in physicochemical characteristics of MTS, TFS and CLP affected the skin permeability. MTS and TFS showed higher flux of MX than CLP. CLSM image showed deformable vesicles mechanism for delivery of MX across the hairless mice skin. Our study suggested that ultradeformable and deformable liposomes (MTS and TFS) had a potential to use as transdermal drug delivery carriers for MX.
著者
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Obata Yasuko
Department Of Pharmaceutics Hoshi University
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Onuki Yoshinori
Department Of Pharmaceutics Hoshi University
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NGAWHIRUNPAT Tanasait
Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University
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Miyoshi Tsubasa
Department Of Physics Graduate School Of Science And Technology Kwansei Gakuin University
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Kato Satoru
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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Takayama Kozo
Department of Drug Delivery Research, Hoshi University
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Duangjit Sureewan
Department of Pharmaceutics, Hoshi University
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Sano Hiromu
Department of Pharmaceutics, Hoshi University
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Opanasopit Praneet
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University
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Kato Satoru
Department of agriculture, Kinki University
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Miyoshi Tsubasa
Department of Physics, Kwansei Gakuin University
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