Synthesis and Biological Activities of Metabolites of Mosapride, a New Gastroprokinetic Agent
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概要
- 論文の詳細を見る
In order to confirm the proposed structures of two metabolites 3 and 4 of the gastroprokinetic agent mosapride [4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)-2-morpholinyl]methyl}benzamide, 2], the compounds were synthesized and their biological activity was examined. The structures of the metabolites were confirmed by means of comparison with the synthetic compounds. The serotonin 5-HT_4 receptor agonistic activities of the metabolites were found to be less than that of mosapride.
- 社団法人日本薬学会の論文
- 1995-04-15
著者
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森江 俊哉
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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吉田 直之
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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賀登 志朗
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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森江 俊哉
大日本製薬株式会社創薬研究所
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吉田 直之
大日本製薬(株)薬理研究所
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Kato Satoru
Kanazawa Univ. Kanazawa Jpn
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賀登 志朗
大日本製薬株式会社創薬研究所
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Yoshida Naoko
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Kato S
Discovery Research Laboratories I Dainippon Pharmaceutical Co. Ltd.
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Kato S
Chemistry Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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吉田 直之
大日本製薬株式会社創薬研究所第一薬理研究部
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Yoshida Naotoshi
Medicinal Plant Garden Faculty Of Pharmaceutical Sciences Hokkaido University
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吉田 直之
大日本製薬株式会社創薬研究所
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Kato Satoru
Department Of Molecular Neurobiology Graduate School Of Medicine University Of Kanazawa
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