p21^<WAF1/CIP1> and Ki-67 Expression of Serrated Adenoma of the Colorectum : An Investigation of Cell Differentiation/Maturation and its Relationship with Cell Proliferation
スポンサーリンク
概要
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The immunohistochemical expression of p21^<WAF1/CIP1> and Ki-67 of serrated adenoma (SA) (n=19) of the colorectum was evaluated in order to elucidate its cell differentiation/maturation status and its relationship with cell proliferation. This was then compared with those of a hyperplastic polyp (HP) (n=18), traditional tubular adenoma (TA) (n=21), and normal colonic mucosa (n=11). Longitudinally sectioned hemicrypts were selected from each sample, and the percentage of the p21^<WAF1/CIP1> (+) portion and the proliferative zone (PZ) per entire hemicrypt length were determined. In SA, although the topographic regulation of cell differentiation/maturation and proliferation was maintained, the percentage of PZ (26.5±1.8%) decreased and that of the p21^<WAF1/CIP1> (+) portion (61.4±2.1%) increased compared with those of normal colonic mucosa (31.8±1.3% and 30.6±1.4%) (p<0.05, respectively), indicating that the cell kinetic balance of SA was inclined toward cell differentiation/maturation. A similar cell kinetic imbalance was seen in HP, whereas the cell kinetic balance was inclined toward cell proliferation in TA. These findings suggest that, unlike TA, SA is a disorder of cell differentiation/maturation rather than cell proliferation, and the elongation of the cell life span and the subsequent reduction of exfoliation, which are the known fundamental cell kinetics of HP, may contribute to its neoplastic growth.
- 新潟大学の論文
著者
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NIMURA Yuji
Department of Surgery, Nagoya University Graduate School of Medicine
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Nimura Yuji
金沢大学 医学系研究科形態機能病理学教室
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Ajioka Y
Divisions Of Molecular And Diagnostic Pathology Graduate School Of Medical And Dental Sciences Niiga
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Ajioka Yoichi
獨協医科大学 病理学人体分子
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Ajioka Yoichi
新潟大学 医歯学総合研究科消化器・一般外科学分野
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Ajioka Yoichi
Division Of Molecular Diagnostic Pathology Niigata University Medical And Dental Hospital
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Ajioka Yoichi
新潟大学 医歯総合研究 遺伝子制御
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Ajioka Yoichi
新潟大学 医歯学総合研究科消化器内科学
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Oda Koji
名古屋大学 腫瘍外科
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Oda Koji
Division Of Surgical Oncology Department Of Surgery Nagoya University Graduate School Of Medicine
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KOMORI Koji
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Course for Molecul
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WATANABE Hidenobu
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Course for Molecul
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ODA Koji
Department of Surgery, Division of Surgical Oncology, Nagoya University, Graduate School of Medicine
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Komori Koji
Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Course For Molecular
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Nimura Yuji
Department Of Biochemistry And Integrative Medical Biology School Of Medicine Keio University
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Ajioka Yoichi
Division Of Molecular And Functional Pathology Niigata University
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Yoichi Ajioka
The First Department Of Pathology Niigata University Schoolof Medicine
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BABA Youichiro
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Niigata University
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Ajioka Youichi
Divison Of Molecular And Diagnostic Pathology Niigata University
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Watanabe H
Niigata Univ. Niigata Jpn
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Watanabe Hidenobu
Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Course For Molecular
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Nimura Yuji
Surgery I Nagoya University School Of Medicine
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Oda Koji
First Department Of Surgery Nagoya University School Of Medicine
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Ajioka Y
Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me
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Oda Koji
Department Of Gastroenterology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Watanabe Hirokazu
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)
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Ajioka Yoichi
Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Graduate School Of M
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Watanabe Hidenobu
Department Of Pathology Niigata University School Of Medicine
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AJIOKA Yoichi
Niigata University Graduate School of Medical and Dental Sciences
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Oda Koji
Division Of Surgical Oncology Nagoya University Graduate School Of Medicine
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Oda K
Tokai Univ.
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Nimura Yuji
First Department Of Surgery Research Institute For Disease Mechanism And Control Nagoya University S
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Okada Kosuke
Department Of Gastroenterology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Ajioka Yoichi
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences
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