Lymph Node Metastasis and Micrometastasis of Submucosal Invasive Colorectal Carcinoma: An Indicator of the Curative Potential of Endoscopic Treatment

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概要

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• This study investigated the correlation between clinicopathologic features of submucosal invasive colorectal carcinoma (sm-CRC) and its metastasis to the lymph nodes, including micrometastasis dectected by anti-human cytokeratin (CAM5.2) immunohistochemistry, in order to assess the curative potential of endoscopic mucosal resection (EMR) for sm-CRC. One hundred seventeen surgically resected sm-CRCs and their corresponding regional lymph nodes were examined. Eighteen of the 117 cases (15.4%) were positive for lymph node metastasis by H&E examination (overt metastasis), and micrometastasis was detected in 17 of the 99 (17.2%) remaining cases that were negative for overt metastasis. Lymphatic invasion and sprouting were risk factors for overt/micrometastasis, and micrometastasis, respectively, (p<0.0001/p=0.03,and p=0.01), and the minimum extent of cancer invasion in patients with lymph node metastasis (micrometastasis) was 850 μm in depth and 2500 μm in width. Tumors with a smaller extent of submucosal invasion than these values showed no lymphatic or venous invasion or sprouting. The present study indicates that sm-CRCs with an extent of submucosal invasion of less than 850 μm in depth and 2500 μm in width may not even have any risk of micrometastasis, and that EMR alone has complete curative potential in such cases.

• 新潟大学の論文

著者

• Watanabe Gen

  新潟大学 医歯学総合研究科消化器･一般外科学分野

• Watanabe Gen

  Divisions Of Molecular And Diagnostic Pathology Graduate School Of Medical And Dental Sciences Niiga

• Ajioka Y

  Divisions Of Molecular And Diagnostic Pathology Graduate School Of Medical And Dental Sciences Niiga

• Ajioka Yoichi

  獨協医科大学 病理学人体分子

• Ajioka Yoichi

  新潟大学 医歯学総合研究科消化器･一般外科学分野

• Ajioka Yoichi

  Division Of Molecular Diagnostic Pathology Niigata University Medical And Dental Hospital

• Ajioka Yoichi

  新潟大学 医歯総合研究 遺伝子制御

• Ajioka Yoichi

  新潟大学 医歯学総合研究科消化器内科学

• WATANABE Hidenobu

  Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Course for Molecul

• Watanabe Gen

  Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Niigata University

• Ajioka Yoichi

  Division Of Molecular And Functional Pathology Niigata University

• Yoichi Ajioka

  The First Department Of Pathology Niigata University Schoolof Medicine

• BABA Youichiro

  Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Niigata University

• YOKOYAMA Junji

  Division of Molecular and Diagnostic Pathology, Niigata Graduate School of Medical and Dental Scienc

• ASAKURA Hitoshi

  First Department of Surgery, Niigata University School of Medicine

• Ajioka Youichi

  Divison Of Molecular And Diagnostic Pathology Niigata University

• Watanabe H

  Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me

• Watanabe H

  Niigata Univ. Niigata Jpn

• Watanabe Hidenobu

  Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me

• Watanabe Hidenobu

  Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Course For Molecular

• Yokoyama Junji

  Division Of Molecular And Diagnostic Pathology Niigata Graduate School Of Medical And Dental Science

• Yokoyama Junji

  Division Of Gastroenterology And Hepatology Department Of Cellular Function Course For Molecular And

• Ajioka Y

  Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me

• Ajioka Yoichi

  Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Graduate School Of M

• AJIOKA Yoichi

  Niigata University Graduate School of Medical and Dental Sciences

• Ajioka Yoichi

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• Watanabe Gen

  Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University

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