p53 Mutation in Gallbladder Carcinoma with an Anomalous Junction of the Pancreaticobiliary Duct
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概要
- 論文の詳細を見る
The purpose of this study is to clarify whether or not p53 gene mutations differ between gallbladder carcinoma (GBC) with an anomalous junction of the pancreaticobiliary duct (AJPBD) and GBC without AJPBD. We examined 17 GBCs with AJPBD and 22 GBCs without AJPBD. Immunohistochemically, the frequency of p53 protein over-expression was 64.7% in GBCs with AJPBD and 77.3% in GBCs without AJPBD. p53 mutations were found in 47.1% of GBCs with AJPBD and 50.0% of GBCs without AJPBD. The mutations were distributed from exons 5 to 8 without a preponderance in certain exons or specific mutational hot spots in either group. All mutations of GBCs with AJPBD were G : C to A : T transition, and 27.3% occurred at the CpG site. For GBCs without AJPBD, 30.3% of mutations were transversion, and mutations did not occur at the CpG site. These results indicate differences in the mutagenesis of p53 gene alteration between GBCs with AJPBD and GBCs without AJPBD.
- 新潟大学の論文
著者
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Ajioka Y
Divisions Of Molecular And Diagnostic Pathology Graduate School Of Medical And Dental Sciences Niiga
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Ajioka Yoichi
獨協医科大学 病理学人体分子
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Ajioka Yoichi
新潟大学 医歯学総合研究科消化器･一般外科学分野
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Ajioka Yoichi
新潟大学 医歯総合研究 遺伝子制御
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Ajioka Yoichi
新潟大学 医歯学総合研究科消化器内科学
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WATANABE Hidenobu
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Course for Molecul
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Kasuya Kazuhiko
東京医科大学 外科学第三
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Ajioka Yoichi
Division Of Molecular And Functional Pathology Niigata University
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Yoichi Ajioka
The First Department Of Pathology Niigata University Schoolof Medicine
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BABA Youichiro
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Niigata University
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Ajioka Youichi
Divison Of Molecular And Diagnostic Pathology Niigata University
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Watanabe H
Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me
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Kasuya Kazuhiko
Third Department Of Surgery Tokyo Medical University
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Watanabe Hidenobu
Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Course For Molecular
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Hidenobu Watanabe
First Department Of Pathology Niigata University School Of Medical
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Watanabe Hidenobu
Divison Of Molecular And Diagnostic Pathology Niigata University
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Shirai Y
Niigata Univ. Niigata Jpn
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Shirai Yoshio
Division Of Digestive And General Surgery Department Of Regeneration And Transplant Medicine Niigata
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DATE Kazutoshi
Divison of Molecular and Diagnostic Pathology, Niigata University
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Yoshikawa T
Tokyo Women's Medical Coll. Jpn
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Date K
Divison Of Molecular And Diagnostic Pathology Niigata University
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Date Kazutoshi
Division Of Digestive And General Surgery Department Of Regeneration And Transplant Medicine Niigata
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AJIOKA Yoichi
Niigata University Graduate School of Medical and Dental Sciences
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