Definition and Histogenesis of Ovarian-type Stroma in Mucinous Cystic Neoplasms of the Pancreas
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概要
- 論文の詳細を見る
Objectives: The present study aimed to clarify the definitions and histogenesis of ovarian-type stroma (OTS) in mucinous cystic neoplasms (MCNs) of the pancreas. Methods: Expression and density of cells positive for estrogen receptor (ER) and progesterone receptor (PR) were immunohistochemically studied in 16 MCNs (6 adenomas, 10 carcinomas), 22 intraductal papillary mucinous neoplasms (IPMNs), 10 common-type invasive ductal carcinomas (IDCs) and 24 non-neoplastic pancreatic tissues. Results: OTS comprised densely packed spindleshaped cells with round or elongated nuclei. Stromal cells were diffusely positive for ER and PR in all 16 MCNs. OTS-like stromal cells in IPMNs and IDCs were negative or only sporadically positive for ER or PR in all cases. In non-neoplastic pancreatic tissue, ER- and PR-reactive stromal cells were scattered sporadically irrespective of site in the pancreas (head, body or tail) or sex. Conclusions: OTS is an absolute marker for diagnosis of pancreatic MCNs and should be confirmed as ER- and PR-reactive on immunostaining in addition to findings from sections stained using hematoxylin-eosin. ER- and PR-reactive stromal cells may become hypersensitive to female sex hormone stimulation and start to proliferate and form OTS in the pancreas.
- 新潟大学の論文
著者
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Watanabe Gen
新潟大学 医歯学総合研究科消化器･一般外科学分野
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EMURA Iwao
Department of Pathology, Nagaoka Red Cross Hospital
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HATAKEYAMA Katsuyoshi
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental
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Hatakeyama K
Division Of Digestive And General Surgery Niigata University Graduate School Of Medical And Dental S
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Watanabe Gen
Divisions Of Molecular And Diagnostic Pathology Graduate School Of Medical And Dental Sciences Niiga
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Ajioka Y
Divisions Of Molecular And Diagnostic Pathology Graduate School Of Medical And Dental Sciences Niiga
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Ajioka Yoichi
獨協医科大学 病理学人体分子
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Ajioka Yoichi
新潟大学 医歯学総合研究科消化器･一般外科学分野
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Ajioka Yoichi
Division Of Molecular Diagnostic Pathology Niigata University Medical And Dental Hospital
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Ajioka Yoichi
新潟大学 医歯総合研究 遺伝子制御
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Ajioka Yoichi
新潟大学 医歯学総合研究科消化器内科学
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WATANABE Hidenobu
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Course for Molecul
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Emura Iwao
Department Of Pathology Nagaoka Red Cross Hospital
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Emura I
Department Of Pathology Nagaoka Red Cross Hospital
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Sakai Yasuo
First Department Of Surgery Niigata University School Of Medicine
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Watanabe Gen
Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Niigata University
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Ajioka Yoichi
Division Of Molecular And Functional Pathology Niigata University
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Yoichi Ajioka
The First Department Of Pathology Niigata University Schoolof Medicine
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BABA Youichiro
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Niigata University
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Ajioka Youichi
Divison Of Molecular And Diagnostic Pathology Niigata University
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Watanabe H
Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me
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Watanabe H
Niigata Univ. Niigata Jpn
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KUROSAKI Ryo
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics
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SHIRAI Yoshio
Division of Digestive and General Surgery, Department of Regeneration and Transplant Medicine, Niiga
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OHTA Tamaki
Department of Pathology
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TSUCHIYA Yoshiaki
Department of Surgery, Niigata Hospital, Niigata Cancer Center
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YAMANO Miki
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics
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Sato Yoshinobu
Division Of Digestive And General Surgery Department Of Surgery Niigata University Graduate School O
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Watanabe Hidenobu
Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me
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Watanabe Hidenobu
Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Course For Molecular
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Miki Yamano
Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics
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Kurosaki Ryo
Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics:division Of Digestiv
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Shirai Y
Niigata Univ. Niigata Jpn
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Shirai Yoshio
Division Of Digestive And General Surgery Department Of Regeneration And Transplant Medicine Niigata
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Ajioka Y
Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me
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Hatakeyama Katsuyoshi
Division Of Digestive And General Surgery Graduate School Of Medical And Dental Sciences Niigata Uni
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Yamaguchi Toshikazu
Department Of Surgery Niigata Hospital Niigata Cancer Center
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Hatakeyama Katsuyoshi
Division Of Digestive And General Surgery Department Of Regenerative And Transplant Medicine Graduat
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Ajioka Yoichi
Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Graduate School Of M
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Hatakeyama Ktsuyoshi
Division Of Digestive And General Surgery Department Of Surgery Niigata University Graduate School O
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Hatakeyama Katsuyoshi
Division Of Digestive And General Surgery Department Of Regeneration And Transplant Medicine Niigata
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AJIOKA Yoichi
Niigata University Graduate School of Medical and Dental Sciences
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Ajioka Yoichi
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences
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Watanabe Gen
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University
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