<Original article>Clinical Significance of VEGF and dThdPase Expressions in Squamous Cell Carcinoma of the Esophagus
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概要
- 論文の詳細を見る
Objectives: The purposes of this study were to clarify the relation between the vascular endothelial growth factor (VEGF) and thymidine phosphorylase (dThdPase) expression in tumor progression, and to evaluate the prognostic influence of these angiogenic factors in patients with esophageal cancer. Methods: VEGF and dThdPase expression and microvessel density (MVD) were immunohistochemically studied in esophageal cancer specimens resected from 103 patients by extended radical esophagectomy. The expression status of VEGF and dThdPase was compared with intratumoral MVD, clinicopathologic parameters of tumor progression, and patient survival after esophagectomy. Results: dThdPase expression was significantly correlated with depth of invasion (P=0.0249) and the size (P=0.0004) of primary tumors. VEGF expression significantly correlated with the depth (P=0.0030) and size (P=0.0345) of the primary tumor. There was no relation between dThdPase and VEGF expression status. dThdPase expression had a significant association with MVD (P=0.0203), whereas VEGF expression had no such association. The survival curves of patients did not differ according to the expression status of dThdPase and/or VEGF. Conclusions: The expression of VEGF and dThdPase was associated with the progression of esophageal cancer by different tumor angiogenic mechanisms. However, the expression of these angiogenic factors had no significant influence upon the survival of patients who underwent extended radical esophagectomy for esophageal cancer.
- 新潟大学の論文
著者
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HATAKEYAMA Katsuyoshi
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental
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Hatakeyama K
Division Of Digestive And General Surgery Niigata University Graduate School Of Medical And Dental S
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KANDA Tatsuo
Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental S
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Kanda T
Division Of Digestive And General Surgery Niigata University Graduate School Of Medical And Dental S
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OHASHI MANABU
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental
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NAKAGAWA Satoru
Division of Digestive and General Surgery, Graduate School of Medical and Dental Sciences, Niigata U
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NISHIMAKI Tadashi
Division of Digestive and General Surgery, Department of Regeneration and Transplant Medicine, Niiga
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KUWABARA Shirou
Division of Digestive and General Surgery, Department of Regeneration and Transplant Medicine, Niiga
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Nakagawa Satoru
Division Of Digestive And General Surgery Graduate School Of Medical And Dental Sciences Niigata Uni
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Kanda Tatsuo
Division Of Digestive And General Surgery Department Of Regenerative And Transplant Medicine Niigata
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Ohashi M
Division Of Digestive And General Surgery Department Of Regenerative And Transplant Medicine Niigata
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Hatakeyama Katsuyoshi
Division Of Digestive And General Surgery Graduate School Of Medical And Dental Sciences Niigata Uni
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Kuwabara Shirou
Division Of Digestive And General Surgery Department Of Regeneration And Transplant Medicine Niigata
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Hatakeyama Katsuyoshi
Division Of Digestive And General Surgery Department Of Regenerative And Transplant Medicine Graduat
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Ohashi Manabu
Division Of Digestive And General Surgery Niigata University Graduate School Of Medical And Dental S
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Kimura Tatsuji
Tonen Corporation Research & Development Laboratory
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Hatakeyama Ktsuyoshi
Division Of Digestive And General Surgery Department Of Surgery Niigata University Graduate School O
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Nishimaki Tadashi
Division Of Digestive And General Surgery Department Of Regeneration And Transplant Medicine Niigata
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Nishimaki Tadashi
Division Of Digestive And General Surgery Department Of Organ-oriented Medicine Faculty Of Medicine
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Hatakeyama Katsuyoshi
Division Of Digestive And General Surgery Department Of Regeneration And Transplant Medicine Niigata
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