MUC1, MUC2, and MUC5AC Mucin Core Protein Expression in Ulcerative Colitis-associated Colorectal Carcinoma

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概要

• 論文の詳細を見る

• Mucin core protein expression in ulcerative colitis-associated colorectal carcinoma (UC-CRC) has not been investigated to date. We immunohistochemically examined expression of MUC2, MUC5AC, and MUC1 mucin core proteins in 8 UC-CRCs (4 mucinous carcinomas and 4 well and/or moderately differentiated adenocarcinomas) in order to characterize their mucin phenotypes. We then compared these with sporadic colorectal carcinomas (sporadic CRCs) (30 mucinous carcinomas and 60 well and/or moderately differentiated adenocarcinomas) in order to confirm whether any specific cellular lineage differentiation occurs in UC-associated carcinogenesis. MUC2, MUC5AC, MUC1 are normally synthesized in goblet cells of gastrointestinal tract, in gastric foveolar epithelium, and in columnar and goblet cells of the colorectum, respectively. UC-CRC exhibited extensive expression of MUC2 (50-100%), MUC5AC (50-75%), and MUC1 (75%), irrespective of histological type, and MUC2+/MUC5AC+/MUC1+ was the most common mucin phenotype (4/8). Six of 8 UC-CRCs had the MUC2+ phenotype, and co-expression of MUC5AC or MUC1 was demonstrated in 5 of these. These findings were similar to those of sporadic mucinous CRCs. The present results indicate that both UC-CRCs and sporadic mucinous CRCs are predominated by cancer cells of goblet cell lineage (MUC2+) with gastric differentiation (MUC5AC+), and up-regulation of gelforming mucin MUC2 and MUC5AC would account for the frequently observed mucinous histology. This suggests that UC-associated carcinogenesis may originate from MUC5AC+ gastric metaplasia and is similar to UACL (ulcer-associated cell lineage) generated in colorectal mucosa exhibiting long-term chronic inflammation.

• 新潟大学の論文

著者

• Watanabe Gen

  新潟大学 医歯学総合研究科消化器･一般外科学分野

• HATAKEYAMA Katsuyoshi

  Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental

• Hatakeyama K

  Division Of Digestive And General Surgery Niigata University Graduate School Of Medical And Dental S

• Watanabe Gen

  Divisions Of Molecular And Diagnostic Pathology Graduate School Of Medical And Dental Sciences Niiga

• Ajioka Y

  Divisions Of Molecular And Diagnostic Pathology Graduate School Of Medical And Dental Sciences Niiga

• Ajioka Yoichi

  獨協医科大学 病理学人体分子

• Ajioka Yoichi

  新潟大学 医歯学総合研究科消化器･一般外科学分野

• Ajioka Yoichi

  Division Of Molecular Diagnostic Pathology Niigata University Medical And Dental Hospital

• Ajioka Yoichi

  新潟大学 医歯総合研究 遺伝子制御

• Ajioka Yoichi

  新潟大学 医歯学総合研究科消化器内科学

• WATANABE Hidenobu

  Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Course for Molecul

• Watanabe Gen

  Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Niigata University

• Ajioka Yoichi

  Division Of Molecular And Functional Pathology Niigata University

• Yoichi Ajioka

  The First Department Of Pathology Niigata University Schoolof Medicine

• BABA Youichiro

  Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Niigata University

• Ajioka Youichi

  Divison Of Molecular And Diagnostic Pathology Niigata University

• Watanabe H

  Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me

• Watanabe H

  Niigata Univ. Niigata Jpn

• KANOH Tsunehisa

  Division of Molecular and Diagnostic Pathology Course for Molecular and Cellular Medicine, Niigata U

• Watanabe Hidenobu

  Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me

• Watanabe Hidenobu

  Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Course For Molecular

• Ajioka Y

  Division Of Molecular And Functional Pathology Department Of Cellular Function Graduate School Of Me

• Hatakeyama Katsuyoshi

  Division Of Digestive And General Surgery Graduate School Of Medical And Dental Sciences Niigata Uni

• Hatakeyama Katsuyoshi

  Division Of Digestive And General Surgery Department Of Regenerative And Transplant Medicine Graduat

• Ajioka Yoichi

  Division Of Molecular And Diagnostic Pathology Department Of Molecular Genetics Graduate School Of M

• Kanoh Tsunehisa

  Division Of Molecular And Diagnostic Pathology Course For Molecular And Cellular Medicine Niigata Un

• Hatakeyama Ktsuyoshi

  Division Of Digestive And General Surgery Department Of Surgery Niigata University Graduate School O

• Hatakeyama Katsuyoshi

  Division Of Digestive And General Surgery Department Of Regeneration And Transplant Medicine Niigata

• AJIOKA Yoichi

  Niigata University Graduate School of Medical and Dental Sciences

• Ajioka Yoichi

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• Watanabe Gen

  Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University

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