Suppression of Liver Blood Flow by Carbon Dioxide Pneumoperitoneumcan be Improved by Prostaglandin E_1 in Pigs
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概要
- 論文の詳細を見る
Portal venous blood flow (PVF), hepatic arterial blood flow (HAF), and systemic arterial pressure (SAP) were examined after prostaglandin E_1 (PGE) injection into the jugular vein under variably enhanced intraabdominal pressure (IAP) in pigs. The IAP was controlled by carbon dioxide pneumoperitoneum. When IAP was increased to 8 or 12 mmHg, PVF was reduced but HAF and SAP were unchanged. In this IAP condition the injection of PGE at 0.25 μg/kg/min for 2 min produced an increase in PVF without causing any change in HAF or SAP. The response in PVF was dose-dependent. When IAP was increased to 16 mmHg, PVF and HAF were reduced without any change in SAP. In such a case, no noticeable changes in PVF, HAF, or SAP were seen with the same dose of PGE. These results suggest that PGE is effective in increasing PVF in an enhanced IAP condition, but such circulatory improvement due to PGE appears limited to IAP at about less than 12 mmHg.
- 新潟大学の論文
著者
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Cui X
Niigata Univ. School Of Medicine Niigata Jpn
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Shirai Y
Niigata Univ. Niigata Jpn
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Shirai Yoshio
Division Of Digestive And General Surgery Department Of Regeneration And Transplant Medicine Niigata
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Xing Cui
The First Department Of Surgery Niigata University School Of Medicine
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Sakaguchi T
Division Of Integrative Physiology Department Of Sensory And Integrative Medicine Niigata University
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Takeo Sakaguchi
The First Department Of Physiology
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Takeo Sakaguchi
The First Department Of Surgery Niigata University School Of Medicine
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Sakaguchi Takeo
Division Of Integrative Physiology Department Of Sensory And Integrative Medicine
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Masahiro OHTAKE
The First Department of Surgery Niigata University School of Medicine
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Ishizuka D
Niigata Univ. School Of Medicine Niigata Jpn
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Ohtake M
Nippon Dental Univ. Niigata Jpn
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Masahiro Ohtake
The First Department Of Surgery
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CUI Xing
The First Department of Surgery, Niigata University School of Medicine
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SAKAGUCHI Takeo
The First Department of Physiology, Niigata University School of Medicine
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OHTAKE Masahiro
The First Department of Surgery Niigata University School of Medicine
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CUI Xing
The First Department of Surgery Niigata University School of Medicine
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