Selective Increments of Superior Mesenteric Artery Blood Flow byDopamine Administration in the Pig

概要

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Circulatory responses in major branches of the superior mesenteric artery were examined after dopamine (DA) administration into the jugular vein in anesthetized pigs. DA at 10 μg/kg/min for 2 min produced an increase in superior mesenteric arterial blood flow (SMAF) and jejunal arterial blood flow (JAF) without any change in right colic arterial blood flow (RCAF), ileocolic arterial blood flow (ICAF) or systemic arterial blood pressure (SAP). The SMAF and JAF response tended to be dose dependent when the does of DA ranged from 5 to 20 μg/kg/min. A significant increase in RCAF was induced when the dose of DA was increased to 20 μg/kg/min, but no change in ICAF was seen. Liver and kidney function scores were unchanged after the DA injection. These findings suggest that DA is active in increasing superior mesenteric arterial blood flow, but the action of DA is differential at the major branch level.
新潟大学の論文