E-cadherin Methylation and Protein Decrease are Related to Infiltrative Growth and Peritoneal Dissemination in Gastric Cancer
スポンサーリンク
概要
- 論文の詳細を見る
The first step of cancer metastasis requires an abnormality of adhesive factors, especially E-cadherin. The causes of abnormal E-cadherin expression consist of gene mutation and methylation of its promoter. An abnormality of E-cadherin protein expression has been frequently found in infiltratively growing tumors such as breast cancers rather than in highly differentiated tumors such as colorectal cancers. However, there have been few reports about abnormal E-cadherin methylation in gastric cancer. In the present study, we examined the relationships between the abnormal expression of E-cadherin, methylation of E-cadherin, abnormal expression of α-catenin and pathological prognostic factors, tumor growth type, and distant metastasis. Materials and Methods : We evaluated the expression of E-cadherin andα-catenin immunohistochemically and the mutational status of E-cadherin methylation in 38 patients with gastric cancer. Results : Abnormal expressions of E-cadherin and α-catenin were observed in 20 cases (52.6%) and 11 cases (28.9%), respectively. The E-cadherin expression was significantly correlated with tumor growth type, histological type, depth of invasion and size of tumor. Fifteen cases were positive for E-cadherin methylation (39.5%), which was seen in cases with dissemination or tumors localized in the upper stomach (in particular the fundic gland zone). Conclusion : A decrease of either E-cadherin expression or methylation has is closely related to infiltrative tumor growth and dissemination.
- 新潟大学の論文
著者
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Aoki Tatsuya
Department Of Surgery Tokyo Medical College
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Aoki Tatsuya
Department Of Surgery Tokyo Medical University
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Kasuya Kazuhiko
東京医科大学 外科学第三
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Kasuya Kazuhiko
Third Department Of Surgery Tokyo Medical University
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Kasuya Kazuhiko
Department Of Surgery Tokyo Medical University
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Koyanagi Yasuhisa
Division Of Gene Therapy Intractable Disease Research Center Tokyo Medical University Department Of
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ITO Kazushige
Department of Surgery, Tokyo Medical University
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Kasuya Kazuhiko
Department Of Digestive Surgery Hachioji Medical Center Of Tokyo Medical University
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Ito Kazushige
Department Of Surgery Tokyo Medical University
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Kasuya Kazuhiko
Department of Chemistry, Faculty of Science and Technology, Sophia University
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