A Vesicular Transporter That Mediates Aspartate and Glutamate Neurotransmission
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概要
- 論文の詳細を見る
Aspartate, an excitatory amino acid, is known to be stored in synaptic vesicles and exocytosed from some neurons to perform aspartergic neurotransmission. Through in vitro reconstitution, we found that sialin, a lysosomal sialic acid exporter, is responsible for the vesicular storage of aspartate in hippocampal neurons and pinealocytes. Mutations found in Salla disease cause decreased aspartate transport activity without affecting sialic acid transport. Thus, sialin is a multifunctional transporter. It is possible that people with Salla disease lose the ability of aspartergic neurotransmission, and this could explain why Salla disease involves severe neurological defects.
- 公益社団法人 日本薬学会の論文
著者
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MORIYAMA YOSHINORI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kanazawa University
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Moriyama Yoshinori
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)
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Omote Hiroshi
Department Of Membrane Biochemistry Okayama University Graduate School Of Medicine Dentistry And Pha
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Miyaji Takaaki
Department of Genomics and Proteomics, Advanced Science Research Center, Okayama University
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Omote Hiroshi
Department Of Mechanical And Physical Engineering Graduate School Of Engineering Osaka City University:research & Development Center Yanmar Co. Ltd.
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Moriyama Yoshinori
Department of Genomics and Proteomics, Advanced Science Research Center, Okayama University
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