Inhibitors of ATP Release Inhibit Vesicular Nucleotide Transporter

スポンサーリンク

概要

• 論文の詳細を見る

• Vesicular nucleotide transporter (VNUT) is responsible for vesicular ATP storage in ATP-secreting cells. In the present study, we examined the effects on VNUT-mediated transport of ATP release inhibitors such as ATP-binding cassette (ABC) proteins, hemichannels, maxi anion channels and P2X7 receptor. The ATP transport activity of proteoliposomes containing purified human VNUT was blocked by glibenclamide, carbenoxolone, 18 α-glycyrrhetinic acid, flufenamic acid, arachidonic acid and A438079 without the formation of Δψ (positive inside) as a driving force being affected. Thus, inhibitors of ATP release may inhibit VNUT and subsequent ATP release, since the previous works proved that inhibitors of ATP release blocked VNUT-mediated ATP release at the cell level.

著者

• Miyaji Takaaki

  Advanced Device Laboratry Corporate R&d H. Q. Omron Corporation

• Omote Hiroshi

  Department Of Mechanical And Physical Engineering Graduate School Of Engineering Osaka City University:research & Development Center Yanmar Co. Ltd.

• Kato Yuri

  Department of Membrane Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• Miyaji Takaaki

  Advanced Science Research Center, Okayama University

関連論文

• Vesicular Glutamate Transporter Acts as a Metabolic Regulator(Physiology and Pharmacology of the Gut Nutrient Perception)
• A Vesicular Transporter That Mediates Aspartate and Glutamate Neurotransmission
• Development of Electrostatic Actuator, which enables the Stable Contact Resistance, Driven at Low Voltage
• CT2-1: Application of a Reduced Elementary Reaction Scheme to Three-dimensional Numerical Simulation of Knocking Phenomenon in a Spark Ignition Engine Fueled by LPG-DME Mixture(CT: Combustion, Thermal and Fluid Science,General Session Papers)
• Inhibitors of ATP Release Inhibit Vesicular Nucleotide Transporter

スポンサーリンク