Synthesis and Evaluation of β-Carbolinium Cations as New Antimalarial Agents Based on π-Delocalized Lipophilic Cation (DLC) Hypothesis
スポンサーリンク
概要
- 論文の詳細を見る
Several β-carbolines including naturally occurring substances and their corresponding cationic derivatives were synthesized and evaluated for antimalarial (antiplasmodial) activity in vitro and in vivo. A tetracyclic carbolinium salt was elucidated for antileishmanial and antitrypanosomal activities in vitro as well as antiplasmodial activity. Quarternary carbolinium cations showed much higher potencies in vitro than electronically neutral β-carbolines and a good correlation was observed between π-delocalized lipophilic cationic (DLC) structure and antimalarial efficacy. β-Carbolinium compounds exhibit medium suppressive activity in vivo against rodent malaria.
- 公益社団法人日本薬学会の論文
- 2005-06-01
著者
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Kim Hye-sook
岡山大学 薬学部
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井原 正隆
東北大薬
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井原 正隆
Graduate School Of Pharmaceutical Sciences Tohoku University
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Takasu Kiyosei
Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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WATAYA Yusuke
Faculty of Pharmaceutical Sciences, Okayama University
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KIM Hye
Faculty of Pharmaceutical Sciences, Okayama University
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IHARA Masataka
Graduate School of Pharmaceutical Sciences, Tohoku University
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Ihara Masataka
Department Of Organic Chemistry Graduate School Of Pharmaceutical Sciences Tohoku University
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Ihara Masataka
Graduate School Of Pharmaceutical Sciences Tohoku University
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SHIMOGAMA Tsubasa
Graduate School of Pharmaceutical Sciences, Tohoku University
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SAIIN Chalerm
Graduate School of Pharmaceutical Sciences, Tohoku University
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BRUN Reto
Swiss Tropical Institute
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Kim Hye
Faculty Of Pharmaceutical Science Okayama University
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Saiin Chalerm
Graduate School Of Pharmaceutical Sciences Tohoku University
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Wataya Y
Faculty Of Pharmaceutical Sciences Okayama University
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Wataya Yusuke
Fac. Of Pharmaceutical Sci. Graduate School Of Medicine Dentistry And Pharmaceutical Sci. Okayama Un
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Shimogama Tsubasa
Graduate School Of Pharmaceutical Sciences Tohoku University
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Kim H‐s
Okayama Univ. Okayama Jpn
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Wataya Yusuke
Faculty Of Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutical Science O
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Brun Reto
Swiss Tropical Inst. Basel Che
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