Synthesis of Optically Active Methyl 7β-Hydroxykaurenoate with Potent Neuroprotective Activity
スポンサーリンク
概要
- 論文の詳細を見る
(-)-Methyl 7β-hydroxykaurenoate (3) and its 4-demethyl acetate (-)-4 were both synthesized via methods that contained radical cyclization and intramolecular Diels-Alder reactions as key steps. Both compounds displayed potent neuroprotective activity against N-methyl-D-aspartate toxicity in cultured cortical neurons.
- 2004-09-01
著者
-
Ihara Masataka
Department Of Organic Chemistry Graduate School Of Pharmaceutical Sciences Tohoku University
-
Sugimoto Hachiro
Tsukuba Research Laboratories Eisai Co. Ltd.
-
Yokota Masahiro
Department Of Organic Chemistry Tohoku University Graduate School Of Pharmaceutical Sciences
-
Sugimoto H
Tsukuba Research Laboratories Eisai Co. Ltd.
-
Kimura M
Tsukuba Research Laboratories Eisai Co. Ltd.
-
Toyota Masahiro
Department Of Chemistry Graduate School Of Science Osaka Prefecture University
-
Toyota Masahiro
Department Of Organic Chemistry Tohoku University Graduate School Of Pharmaceutical Sciences
-
MATSUURA Kiminori
Department of Organic Chemistry, Tohoku University, Graduate School of Pharmaceutical Sciences
-
KIMURA Manami
Tsukuba Research Laboratories, Eisai Co. Ltd.
-
YONAGA Masahiro
Tsukuba Research Laboratories, Eisai Co. Ltd.
関連論文
- Asymmetric Intramolecular Aza-Michael Reaction Using Environmentally Friendly Organocatalysis
- Studies on the Syntheses of Heterocyclic Compounds. DCXXVI. A Modified Synthesis of Pentazocine
- Synthesis of Optically Active Methyl 7β-Hydroxykaurenoate with Potent Neuroprotective Activity
- Syntheses of Biologically Active Natural Products and Leading Compounds for New Pharmaceuticals Employing Effective Construction of a Polycyclic Skeleton
- 薬学と有機合成化学
- 生理活性多元素環状化合物の効率的合成法 (特集 注目される多元素環状化合物の創製)
- 福本圭一郎先生 紫綬褒章受章
- ドミノ型反応と天然物合成
- グリッシュ有機化学 : J.R.Gerrish, R.C.Whitfield著, 徳丸克己, 今成啓子 訳A5判/375頁/2800円(東京化学同人)
- Synthesis and Evaluation of β-Carbolinium Cations as New Antimalarial Agents Based on π-Delocalized Lipophilic Cation (DLC) Hypothesis
- Antimalarial and Cytotoxic Activities of Bicyclo[6. 4. 0]dodecenones
- Production of a Synthesized Plasma
- Electron Temperature of Helium Plasmas Produced by Theta Pinch
- 奨励賞受賞 高須清誠氏の業績
- 合成創薬を楽しむ : 大学発創薬ベンチャーの創出
- Three-Step Total Synthesis of Pyrroloquinazolinoquinoline Alkaloid, Luotonin A, by Intramolecular Hetero Diels-Alder Reaction
- A Facile Synthetic Method of ABCD Ring System of Antitumor Alkaloid Camptothecin via Intramolecular Hetero Diels-Alder Reaction
- Axial Motion and End Loss in the Slow Theta Pinch Plasma
- Research and Development of Donepezil Hydrochloride : a New Type of Acetylcholinesterase Inhibitor
- P-14 TOTAL SYNTHESIS OF (+)-MYCALAMIDE A
- On the Relationship between the Deformation of Theta Pinched Plasma and the Inhomogeneity of Magnetc Field