Formal (3+3) Cycloaddition of Silyl Enol Ethers Catalyzed by Trifric Imide: Domino Michael Addition-Claisen Condensation Accompanied with Isomerization of Silyl Enol Ethers
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概要
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We describe here a Tfsub2/subNH-catalyzed formal (3+3) cycloaddition of silyl enol ethers with acrylates as a new domino reaction. In the domino sequence, the catalyst activates Michael addition, deprotonation of the resulting silyloxonium cation and intramolecular Claisen condensation. It was found that reaction modes significantly depend on the reaction temperature. We also examined the mechanistic detail of the reaction by sup1/supH-NMR experiment.
- 公益社団法人 日本薬学会の論文
著者
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Takemoto Yoshiji
Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Takasu Kiyosei
Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Takasu Kiyosei
Graduate School of Pharmaceutical Sciences, Kyoto University
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Azuma Takumi
Graduate School of Pharmaceutical Sciences, Kyoto University
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Takemoto Yoshiji
Graduate School of Pharmaceutical Sciences, Kyoto University
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