The Inhibitory Effects of Compounds from Olive Leaf on Tumor Necrosis Factor Production and on β-Hexosaminidase Release
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概要
- 論文の詳細を見る
The extraction and isolation of olive leaf gave luteolin 7-O-glucoside, luteolin 4'-O-glucoside and oleuropein as the major components. The inhibitory effects of these compounds on tumor necrosis factor (TNF-α) production and on β-hexosaminidase release from rat basophilic leukemia (RBL-2H3) cells, which were both recently found to be linked to allergic reaction, were examined. Oieuropein showed a potent inhibitory effect on TNF-α production. Luteolin 4'-O-glucoside showed a strong inhibitory effect on β-hexosaminidase release (IC_<50> : 17.1μg/ml).
- 日本生薬学会の論文
- 2001-08-20
著者
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MIZUTANI Kenji
Maruzen Pharmaceutical Co., Ltd
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Nishibe S
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaid
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Nishibe S
Higashi Nippon Gakuen Univ. Hokkaido Jpn
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Noguchi Yukari
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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UEDA Hiroshi
Faculty of Agriculture, Ehime University
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KAMBARA Toshimitsu
Maruzen Pharmaceuticals Co. Ltd.
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KISHIDA Naoko
Maruzen Pharmaceuticals Co. Ltd.
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Nishibe Sansei
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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Yamazaki Masatoshi
Faculty Of Internal Arts And Science Yamagata University
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Han Yingmei
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Kambara Toshimitsu
Maruzen Pharmaceuticals Co. Ltd. Hiroshima Jpn
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Ueda Hiroshi
Faculty Of Agriculture Ehime University
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Ueda Hiroshi
Faculty Of Pharmaceutical Sciences Teikyo University
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Mizutani Kenji
Maruzen Pharmaceuticals Co. Ltd. Hiroshima Jpn
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NOGUCHI Yukari
Faculty of Phamaceutical Science, Health Sciences University of Hokkaido
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