Alkyne-Co<SUB>2</SUB>(CO)<SUB>6</SUB>錯体を用いる高立体選択的反応の開発
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Propynal-Co<SUB>2</SUB>(CO)<SUB>6</SUB> complex, prepared from the reaction of the corresponding propynal with dicobaltoctacarbonyl, has been shown to be an excellent substrate for highly <I>syn</I>-selective aldol reactions with silyl enol ethers and silyl ketene acetal species under the Mukaiyama condition. On the basis of these stereoselective reactions, we have completed synthesis of some of biologically active compounds such as PS-5, blastmycinone, <I>erythro</I>-C<SUB>18</SUB>-sphingosine, and bengamide E. On the other hand, a novel way for construction of tetrahydropyrans and tetrahydrofurans has been developed by regio- and stereoselective ring formation of Co<SUB>2</SUB>(CO)<SUB>6</SUB>- complexed alkyne-epoxide through the 6-endo mode and 5-endo mode type ring closure, respectively.
- 有機合成化学協会の論文
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