Anti-inflammatory Diterpene from Thyrsanthera suborbicularis
スポンサーリンク
概要
- 論文の詳細を見る
Bioactivity-guided isolation on a n-hexane-soluble fraction of Thyrsanthera suborbicularis led to the isolation of a new rosane-type diterpene, 19-hydroxy-1(10), 15-rosadiene (1), along with three known compounds, taraxerol, acetyl aleuritolic acid, and spathulenol. The structures of isolated compounds were determined by interpretation of NMR spectroscopic data and mass spectrometry. Compound 1 demonstrated significantly inhibitory activity on nitric oxide production in RAW264.7 lipopolysaccharide (LPS)-activated mouse macrophages with an IC50 value of 2.91 μg/ml via the suppression of inducible nitric oxide synthase (iNOS) mRNA expression.
著者
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AHN Kyung-Seop
Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology
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OH Sei-Ryang
Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology
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CHIN Young-Won
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University
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Oh Sei-ryang
Korea Research Institute Of Bioscience And Biotechnology:college Of Pharmacy Wonkwang University
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Chin Young-won
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Khiev Piseth
University of Science & Technology
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Chae Hee-Sung
Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of B
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Kwon Ok-Kyoung
Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of B
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Lee Hyeong-Kyu
University of Science & Technology
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Kwon Ok-kyoung
Immune Modulator Res. Center Bio-therapeutics Res. Inst. Korea Res. Inst. Of Bioscience & Biotec
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Oh Sei-Ryang
Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology
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Chae Hee-Sung
Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology
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Ahn Kyung-Seop
Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology
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Chin Young-Won
College of Pharmacy, Dongguk University-Seoul
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Kwon Ok-Kyoung
Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology
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