Triterpenes with Cytotoxicity from the Leaves of Vernicia fordii
スポンサーリンク
概要
- 論文の詳細を見る
Two new triterpenes, (1α,3β,8α,9β,10α,13α,14β)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol (1) and (1α,3β,6β)-olean-12-en-1,3,6-triol (2) were isolated from the leaves of Aleurites fordii, together with five known triterpenes. The structures of isolates were established by one dimensional (1D)- and 2D-NMR spectroscopic data along with MS analysis. Of the isolated compounds, 1, 2 and 4 (daturadiol) displayed moderate cytotoxicities against two or more human cancer cell lines in HepG2 (hepatocellular carcinoma), SK-OV-3 (ovarian carcinoma), A-549 (lung carcinoma) and SNU-1 (gastric carcinoma).
著者
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LEE JI-SEON
Department of Pediatnics(Divesion of Pediatric Endocrinology), Yale University School of Medicine
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Chin Young-won
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Lee Hyeong-Kyu
University of Science & Technology
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Kwon Ok-Kyoung
Natural Medicine Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
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Oh Sei-Ryang
University of Science & Technology
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Ahn Kyung-Seop
Natural Medicine Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
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Oh Sei-Ryang
University of Science & Technology
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Pei Yi-Hua
University of Science & Technology
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Cha Hyuk-Jin
Department of Life Sciences, Sogang University
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Pei Yi-Hua
University of Science & Technology
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Cha Hyuk-Jin
Department of Life Science, College of Natural Science, Sogang University
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Ahn Kyung-Seop
Natural Medcine Research Center, Korea Research Institute of Bioscience & Biotechnology
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Lee Ji-Seon
Department of Life Science, College of Natural Science, Sogang University
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Kwon Ok-Kyoung
Natural Medcine Research Center, Korea Research Institute of Bioscience & Biotechnology
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