Cyclic Sulfoxides Garlicnins B2, B3, B4, C2, and C3 from Allium sativum
スポンサーリンク
概要
- 論文の詳細を見る
Several novel sulfides, called garlicnins B2 (1), B3 (2), B4 (3), C2 (4), and C3 (5), were isolated from acetone extracts of garlic, Allium sativum L. and characterized. These garlicnins are capable of suppressing M2 macrophage activation and they have a novel skeleton of cyclic sulfoxide. The structures of the former 3 and latter of 2 were deduced to be 2-(sulfenic acid)-5-(allyl)-3,4-dimethyltetrahydrothiophene-S-oxides and 2-(allyldithiine)-5-(propenylsulfoxide)-3,4-dimethyltetrahydrothiophene-S-oxides, respectively. The mechanism of the proposed production of these compounds is discussed. The identification of these novel sulfoxides from garlic accumulates a great deal of new chemistry in the Allium sulfide field, and future pharmacological investigations of these compounds will aid the development of natural, healthy foods and anti-cancer agents that may prevent or combat disease.
著者
-
Kinjo Junei
Faculty Of Pharmaceutical Sciences Fukuoka University
-
Ono Masateru
School Of Agriculture Kyushu Tokai University
-
Nakano Daisuke
Faculty of Pharmaceutical Sciences, Fukuoka University
-
Fujiwara Yukio
Graduate School Of Medical Sciences Faculty Of Life Sciences Kumamoto University
-
Ikeda Tsuyoshi
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
-
Nohara Toshihiro
Faculty of Medical and Pharmaceutical Scieces, Sojo University
-
Murakami Kohtaro
Faculty of Pharmaceutical Sciences, Sojo University
関連論文
- Four New ent-Kaurane Diterpenoids from the Fruits of Annona cherimola
- Components of Ether-Insoluble Resin Glycoside (Convolvulin) from Seeds of Quamoclit pennata
- Molecular Orbital Analysis of Antioxidative Activity of Phenolics from Tessaria integrifolia and Piper elongatum
- Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains
- Delta(9)-tetrahydrocannabinol Enhances an Increase of Plasma Corticosterone Levels Induced by Forced Swim-Stress
- Pharmacological Study on the Novel Antinociceptive Agent, a Novel Monoterpene Alkaloid from Incarvillea sinensis(Pharmacognosy)
- A new diterpenoid and a new triterpenoid glucosyl ester from the leaves of Callicarpa japonica Thunb. var. luxurians Rehd.
- A new lignan glucoside from the stems of Callicarpa japonica Thunb. var. luxurians Rehd.
- Five New Diterpenoids, Viteagnusins A-E, from the Fruit of Vitex agnus-castus
- HPLC Profile Analysis of Hepatoprotective Oleanene-Glucuronides in Puerariae Flos
- Three New Anti-Oxidative Saponarin Analogs from Young green Barley Leaves
- Structures of Three New Oleanene Glucuronides Isolated from Lathyrus palustris var. pilosus and Hepatoprotective Activity
- A New Oleanene Glucuronide Having a Branched-Chain Sugar from Melilotus officinalis
- Oleanene-Type Triterpene Glycosides from Puerariae Radix. IV. Six New Saponins from Pueraria lobata
- Oleanene-Type Triterpene Glycosides from Puerariae Radix. III.Three New Saponins from Pueraria thomsonii
- Antinociceptive Activities of α-Truxillic Acid and β-Truxinic Acid Derivatives(Pharmacognosy)
- Anti-inflammatory Activity of 4,4'-Dihydroxy-α-truxillic Acid(Pharmacognosy)
- Quantitative Determination of Incarvillateine in Incarvillea sinensis by Solid Phase Extraction and High Performance Liquid Chromatography
- Anti-inflammatory Activities of α-Truxillic Acid Derivatives and Their Monomer Components(Medicinal Chemistry)
- A Monoterpene Alkaloid from Incarvillea sinensis
- Two Novel Actinidine-Type Monoterpene Alkaloids from Incarvillea delavayi
- Studies on the Constituents of Gueldenstaedtia multiflora
- Three New Monoterpenoids from the Fruit of Genipa americana
- Four New Triterpene Glycosides from Nigella damascena
- New Iridoid Glucosides from the Aerial Parts of Verbena brasiliensis
- Trypanocidal Constituents in Plants 6. Minor Withanolides from the Aerial Parts of Physalis angulata
- ウスバサイシンAsiasarum sieboldii F. Maekawaの発芽特性
- Anti-herpes Virus Type 1 Activity of Oleanane-Type Triterpenoids(Pharmacognosy)
- New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis
- Trypanocidal Constituents in Plants 5. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in the Seeds of Persea americana(Pharmacognosy)
- Examination for Estrogenic Activities of Soyasaponin I and Related Compounds
- Soy Isoflavone Metabolites Isolated from Human Urine
- Steroids from the Underground Parts of Trillium kamtschaticum
- Hepatoprotective Constituents in Plants 14. Effects of Soyasapogenol B, Sophoradiol, and Their Glucuronides on the Cytotoxicity of tert-Butyl Hydroperoxide to HepG2 Cells(Pharmacognosy)
- Sesquiterpenoids, Triterpenoids, and Flavonoids from the Fruits of Schinus molle
- DPPH radical-scavenging effect on some constituents from the aerial parts of Lippia triphylla
- Two new lignan glucosides from the fruit of Vitex cannabifolia
- Two Novel Antioxidant Ortho-Benzoyloxyphenyl Acetic Acid Derivatives from the Fruit of Vaccinium uliginosum
- Two New Steroid Glycosides and a New Sesquiterpenoid Glycoside from the Underground Parts of Trillium kamtschaticum
- Iridoid Glucosides from the Fruit of Genipa americana
- Antioxidative, Antihyaluronidase and Antityrosinase Activities of Some Constituents from the Aerial Part of Piper elongatum VAHL.
- Antioxidative and Antihyaluronidase Activities of Some Constituents from the Aerial Part of Daucus carota
- Antiproliferative Activity of Phenylpropanoid Ester Glycosides from Ligustrum purpurascens
- Effects of Oleanane-Type Triterpenoids from Fabaceous Plants on the Expression of ICAM-1
- Resin glycosides from the leaves and stems of Ipomoea digitata
- Partial Hydrolysis of Soyasaponin I and the Hepatoprotective Effects of the Hydrolytic Products. Study of the Structure-Hepatoprotective Relationship of Soyasapogenol B Analogs
- Studies on the chemical constituents of green leaves of Eucommia ulmoides Oliv.
- Physiological functions of solanaceous and tomato steroidal glycosides
- Tomato New Sapogenols : Isoesculeogenin A and Esculeogenin B
- Antiproliferative Constituents in Plants 14. Coumarins and Acridone Alkaloids from Boenninghausenia japonica NAKAI(Pharmacognosy)
- Triterpene Saponins from Abrus cantoniensis (Leguminosae). II. Characterization of Six New Saponins Having a Branched-Chain Sugar
- Triterpene Saponins from Abrus cantoniensis (Leguminosae). I. Isolatioin and Characterization of Four New Saponins and a New Sapogenol
- Antioxidative Substances in the Leaves of Ligustrum purpurascens
- Microbial metabolism of soy isoflavones by human intestinal bacterial strains
- Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica(Pharmacognosy)
- Interactions of Phytoestrogens with Estrogen Receptors α and β(III). Estrogenic Activities of Soy Isoflavone Aglycones and Their Metabolites Isolated from Human Urine(Toxicology)
- Ursolic Acid as a Trypanocidal Constituent in Rosemary
- Activity-Guided Fractionation of Green Tea Extract with Antiproliferative Activity against Human Stomach Cancer Cells
- Antiproliferative Constituents in Plants 10. Flavones from the Leaves of Lantana montevidensis BRIQ. and Consideration of Structure-Activity Relationship
- Study of Structure-Hepatoprotective Relationships of Oleanene-Type Triterpenoidal Glucuronides Obtained from Several Fabaceous Plants on Rat Primary Hepatocyte Cultures
- Hepatoprotective and Hepatotoxic Actions of Oleanolic Acid-Type Triterpenoidal Glucuronides on Rat Primary Hepatocyte Cultures
- Hepatoprotective and Hepatotoxic Activities of Sophoradiol Analogs on Rat Primary Liver Cell Cultures
- Five Triterpene Glycosides from Oxytropis myriophylla
- Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis
- HPLC Profile Analysis of Oleanene-Glucuronides in Several Edible Beans
- DPPH(1, 1-Diphenyl-2-Picrylhydrazyl)Radical Scavenging Activity of Flavonoids Obtained from Some Medicinal Plants
- A New Diterpenoid Glucoside and Two New Diterpenoids from the Fruit of Vitex agnus-castus
- A New Oleanene Glucuronide Obatined from the Aerial Parts of Melilotus officinalis
- Two New Acyclic Diterpene Glycosides from Fruits of Habanero, Capsicum chinense
- Three new aromatic glycosides from the ripe fruit of cherry tomato
- Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside
- Four New Iridoid Glucosides from Ajuga reptans
- Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents
- Hepatoprotective Effects of Oleanene Glucuronides in Several Edible Beans
- Examination for Estrogenic Activities of Soyasaponin I and Related Compounds
- Soy Isoflavone Metabolites Isolated from Human Urine
- Antiproliferative Activity of Phenylpropanoid Ester Glycosides from Ligustrum purpurascens
- Antioxidative Substances in the Leaves of Ligustrum purpurascens
- HPLC Profile Analysis of Hepatoprotective Oleanene-Glucuronides in Several Soybean Processed Foods
- Garlicnin A from the Fraction Regulating Macrophage Activation of Allium sativum
- Three New Nortriterpene Glycosides and Two New Triterpene Glycosides from the Bulbs of Scilla scilloides
- Three New Diterpenoids from the Fruit of Vitex agnus-castus
- Five New Steroidal Glycosides from the Stems of Solanum sodomaeum
- Components of convolvulin from Quamoclit×multifida
- Development of an enzyme-linked immunosorbent assay to determine puerarin and its aglycone daidzein
- Screening of promising chemotherapeutic candidates against human adult T-cell leukemia/lymphoma from plants : active principles from Physalis pruinosa and structure-activity relationships with withanolides
- Garlicnins B1, C1, and D, from the Fraction Regulating Macrophage Activation of Allium sativum
- Three New Resin Glycosides and a New Tetrahydropyran Derivative from the Seeds of Quamoclit pennata
- Two New Nortriterpenoid Glycosides and a New Phenylpropanoid Glycoside from the Bulbs of Scilla scilloides
- Identification and Characterization of Component Organic and Glycosidic Acids of Crude Resin Glycoside Fraction from Calystegia soldanella
- Antioxidative and Antihyaluronidase Activities of Some Constituents from Foeniculi Fructus(Fruit of Foeniculum vulgare MILLER).
- Five New Nortriterpenoid Glycosides from the Bulbs of Scilla scilloides
- Cyclic Sulfoxides Garlicnins B2, B3, B4, C2, and C3 from Allium sativum
- Three Acylated Glycosidic Acid Methyl Esters and Two Acylated Methyl Glycosides Generated from the Convolvulin Fraction of Seeds of Quamoclit pennata by Treatment with Indium(III) Chloride in Methanol
- Characterization of Carotenoid Fatty Acid Esters from the Peels of the Persimmon Diospyros kaki
- Calysolins V–IX, Resin Glycosides from Calystegia soldanella and Their Antiviral Activity toward Herpes
- Five New Resin Glycoside Derivatives Isolated from the Convolvulin Fraction of Seeds of Quamoclit pennata after Treatment with Indium(III) Chloride in Methanol
- Calysolins X–XIII, Resin Glycosides from Calystegia soldanella, and Their Antiviral Activity toward Herpes Simplex Virus
- Four New Acylated Glycosidic Acid Methyl Esters Isolated from the Convolvulin Fraction of Seeds of Quamoclit pennata after Treatment with Indium(III) Chloride in Methanol