Cornuside Suppresses Cytokine-Induced Proinflammatory and Adhesion Molecules in the Human Umbilical Vein Endothelial Cells(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. et Zucc. The present study was designed to examine the effects of cornuside on expression levels of cytokine-induced proin-flammatory and adhesion molecules in the human umbilical vein endothelial cells (HUVECs). Cornuside treatment attenuated tumor necrosis factor-α (TNF-α)-induced nuclear factor-kappa B (NF-κB) p65 translocation in HUVECs. In addition, cornuside suppressed the expression levels of endothelial cell adhesion molecules including intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) induced by TNF-α. TNF-α-induced monocyte chemoattractant protein 1 (MCP-1) expression was also attenuated by treatment of cornuside. These inhibitory effects of cornuside on proinflammatory and adhesion molecules were not due to decreased HUVEC viability as assessed by MTT test. Taken together, the present study suggests that cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells.
- 社団法人日本薬学会の論文
- 2007-09-01
著者
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Kim Jin
Korea University Guro Hospital
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Moon Mi
Professional Graduate School Of Oriental Medicine Wonkwang Univ.
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Moon Mi
韓国
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Lee Hyun
韓国
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Kang Dae
Professional Graduate School of Oriental Medicine, Wonkwang University
-
Lee Ho
Professional Graduate School of Oriental Medicine, Wonkwang University
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Kwon Tae
College Of Life Science And Naturalresources Wonkwang University
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Kwon Tae
韓国
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Kang Dae
Professional Graduate School Of Oriental Medicine Wonkwang Univ.
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Lee H
Bioanalysis Laboratory College Of Pharmacy Wonkwang University
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Kim Jin
Korea Institute Of Oriental Medicine
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Lee H
Professional Graduate School Of Oriental Medicine Wonkwang University
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Lee H
Korea Res. Inst. Biosci. Biotechnol. Taejon Kor
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Lee Hyun
Cardiovascular Research Laboratory
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LEE An
Professional Graduate School of Oriental Medicine, Wonkwang University
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Lee An
Professional Graduate School Of Oriental Medicine Wonkwang University
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Lee Hye
Bioanalysis Laboratory College Of Pharmacy Wonkwang University
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Lee Ho
Professional Graduate School Of Oriental Medicine Wonkwang Univ.
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Kim Jin
Korea Advanced Inst. Sci. And Technol. Daejeon Kor
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