Isolation of Angiotensin Converting Enzyme (ACE) Inhibitory Flavonoids from Sedum sarmentosum(Pharmacognosy)

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概要

• 論文の詳細を見る

• Bioassay-guided fractionation of the EtOAc-soluble extract of Sedum sarmentosum afforded a new flavonoid, quercetin-3-O-α-(6'''-caffeoylglucosyl-β-1,2-rhamnoside) (1), along with four known flavonoids, quercetin 3-O-α-(6'''-p-coumaroylglucosyl-β-1,2-rhamnoside) (2), isorhamnetin-3-β-glucopyranoside (3), quercetin-3-β-glucopyranoside (4), and kaempferol-3-α-arabinopyranoside (5). Purification of these compounds was conducted with the application of various chromatographic methods. Compounds 1-5 inhibited angiotensin I converting enzyme (ACE) activity in a concentration-dependent manner. Compounds 1-5 had 50% inhibitory concentration values of 158.9±11.1 μM, 351.6±3.9 μM, 408.9±4.6 μM, 708.8±23.1 μM, and 392.8± 13.4 μM.

• 公益社団法人日本薬学会の論文
• 2004-12-01

著者

• Kwon Tae-oh

  Mrrc And College Of Life Science And Natural Resources Wonkwang University

• Kang Dae-Gill

  Professional Graduate School of Oriental Medicine, Hanbang Body-fluid Research Center, Wonkwang Univ

• Lee Ho-Sub

  Professional Graduate School of Oriental Medicine, Hanbang Body-fluid Research Center, Wonkwang Univ

• Kang Dae-gill

  Professional Graduate School Of Oriental Medicine Wonkwang University

• Lee Ho-sub

  Professional Graduate School Of Oriental Medicine Wonkwang University

• OH Hyuncheol

  Korea Research Institute of Bioscience and Biotechnology (KRIBB)

• KWON Ji-Woong

  MRRC and College of Life Science and Natural Resources, Wonkwang University

• LEE Seung-Yeob

  MRRC and College of Life Science and Natural Resources, Wonkwang University

• LEE Duck-Bae

  MRRC and College of Life Science and Natural Resources, Wonkwang University

• Kwon Ji-woong

  Mrrc And College Of Life Science And Natural Resources Wonkwang University

• Lee Duck-bae

  Mrrc And College Of Life Science And Natural Resources Wonkwang University

• Lee Seung-yeob

  Mrrc And College Of Life Science And Natural Resources Wonkwang University

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