Three New and Antitumor Anthraquinone Glycosides from Lasianthus acuminatissimus MERR
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概要
- 論文の詳細を見る
Three new anthraquinone glycosides, lasianthuoside A (1), B (2), and C (3), were isolated from the root of Lasianthus acuminatissimus MERR., The structural elucidation of these anthraquinones was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Ten known compounds, damnacanthol (4), damnacanthol 11-methyl ether (5), damnacanthol-3-O-β-D-primeveroside (6), asperuloside (7), asperulosidic acid (8), deacetyl asperulosidic acid (9), a nonglycosidic iridoid (10), 2, 6-dimethoxy-4-hydroxyphenol-1-O-β-D-glu-copyranoside (11), tachioside (methoxyhydroquinone-4-O-β-D-glucopyranoside) (12), and isotachioside (methoxyhydroquinone-1-O-β-D-glucopyranoside) (13) were also identified for the first time from this plant in the course of the phytochemical and spectroscopic investigation. In addition to this report, a preliminary evaluation of 13 compounds in treating rheumatoid arthritis and antitumor effects of six anthraquinones are presented.
- 公益社団法人日本薬学会の論文
- 2006-03-01
著者
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Li Bin
College Of Pharmacy Wonkwang University
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Li Bin
Jiangxi University Of Traditional Chinese Medicine:beijing University Of Traditional Chinese Medicin
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Luo Yong-ming
Jiangxi University Of Traditional Chinese Medicine
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Zhang Dong-ming
Institute Of Materia Medica Chinese Academy Of Medical Sciences And Peking Union Medical College
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Chen Xiao-guang
Institute Of Materia Medica Chinese Academy Of Medical Sciences And Peking Union Medical College
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