マメ科植物を起源とする生理活性成分の探索研究 : オレアネングルクロナイドの構造・肝障害改善作用・HPLCプロフィールおよび糖部機能について
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概要
- 論文の詳細を見る
Crude saponin fractions of Puerariae Flos (flowers of Pueraria lobata) and Abri Herba (whole plants of Abrus cantoniensis) were found to be effective for experimentally induced liver injury. Chemical analysis of these fractions gave saponins (Oleanene glucuronides) characteristic of the family Leguminosae, which have a methyl group at C-17 and a glucuronic acid moiety at C-3 of sapogenols, which are common to the soybean saponins. By further discovery of the saponins in leguminous plants, we isolated more than 130 saponins including 67 new ones and 19 novel sapogenols from 18 plants. Their effects on hepatic injury were assayed by using primary cultured rat hepatocytes. Kaikasaponin III, isolated from Abri Herba, was found to be more effective than glycyrrhizin and soyasaponin I which have been known to be effective on hepatic injuries. To study the relation between the activity and the structures of the sugar moiety, we synthesized novel saponins having an oligo-saccharide chain at C-28 carboxy group of oleanolic acid-type saponins. Now their activities towards hepatic injury, microorganisms and cancer cells are evaluating.
- 日本生薬学会の論文
- 1996-04-20
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