Multifunctional Drug Delivery System Using Starch-Alginate Beads for Controlled Release(Miscellaneous)
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概要
- 論文の詳細を見る
Utilizing starch-containing alginate beads, a novel drug delivery system (DDS) was developed. With the starch inside, the composite bead could be dried in its original bead shape and handled in the dried state. By employing alginate multi-coating strategy on the starch-alginate beads, detained or controlled release was efficiently achieved and successfully demonstrated for a model peptide drug, _L-phenylalanine. The initial latent time and release rate of the drug inside the beads were able to be controlled simply by varying the number of multicoatings. While the latent time for the initial release was negligible for non-coated starch-alginate beads, the latent times of beads coated one, two, and four times increased to 15, 30, and 70min, respectively. Furthermore, the alginate component of the composite beads could adsorb and remove heavy metals such as lead from the body. These multifunctional beads combined with the novel coating process will greatly benefit alginate gel-based DDS.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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Kim Young
National Genome Information Center Korea Research Institute Of Bioscience And Biotechnology
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Park Hyun
Department Of Computer Science Korea Advanced Institute Of Science & Technology
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YANG Young
National Genome Information Center, Korea Research Institute of Bioscience and Biotechnology
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YOON Yoosik
Department of Medical Research, Korea Institute of Oriental Medicine
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KIM Sangsoo
National Genome Information Center, Korea Research Institute of Bioscience and Biotechnology
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OH Eugene
Cosbiotech. Inc.
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Yoon Yoosik
Department Of Medical Research Korea Institute Of Oriental Medicine
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Kim S
Lucky Central Research Inst. Taejon Kor
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Park Hyun
Department Of Computer Science Chungnam National University
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Yang Young
National Genome Information Center Korea Research Institute Of Bioscience And Biotechnology
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Park Hyun
Department Of Chemical & Biomolecular Engineering Korea Advanced Institute Of Science & Tech
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Park Hyun
Department Of Ceramic Engineering Chonnam National University
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Kim Young
National Center for Nanoprocess and Equipments, Honam Technology Division, Korea Institute of Industrial Technology, Gwangju 500-480, Korea
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Park Hyun
Department of Biotechnology, Yeungnam University
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