Exercise Training and Supplementation with Carnitine and Antioxidants Increases Carnitine Stores, Triglyceride Utilization, and Endurance in Exercising Rats
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概要
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This study evaluated the effects of supplementation of carnitine and antioxidants on lipids, carnitine concentrations, and exercise endurance time in both trained and untrained rats as compared to non-supplemented rats Thirty-two male SD rats, age 7 wk were divided into four groups according to exercise training and modified AIN-76 diets NTNS (non-trained non-supplemented), NTS (non-trained supplemented), LTNS (long-trained non-supplemented) and LTS (long-trained supplemented) The trained rats were run on a treadmill for 60 mm per day (10^0 incline, 20 m/min for 8 wk) Carnitine (0 5%/diet) and vitamin E (0 5 mg/g b w) were supplemented in rat diets and vitamin C (0 5 mg/g b w) and melatonin (1μg/g b w) were administered into the stomachs of the rats LTNS and LTS rats had significantly lower serum total lipid, triglyceride, total cholesterol and liver triglycerides, but had higher serum HDL-cholesterol There were no changes in exercise endurance time by supplementation in untrained animals, however endurance times were longer in LTS animals than in LTNS The supplementation and training tended to increase carnitine palmitoyltransferase (CPT-I) activities, although the differences were not statistically significant Likewise, CPT-I mRNA levels were higher in both supplemented and exercise trained rats These results suggest that supplementation of carnitine and antioxidants may improve lipid profiles and exercise ability in exercise-trained rats
- 日本ビタミン学会の論文
著者
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Kim Eugene
Department Of Dermatology Sungkyunkwan University School Of Medicine Samsung Medical Center
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Kim Eugene
韓国
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Kim Eugene
Department Of Food Science & Human Nutrition And Institute For Molecular Biology And Genetics Ch
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Cha Youn-soo
韓国
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Park Hyun
Department of Systems Innovation, Graduate School of Engineering, The University of Tokyo
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CHA Youn-Soo
Department of Food and Nutritional Science, Chonbuk National University
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Cha Y‐s
Department Of Food Science & Human Nutrition And Institute For Molecular Biology And Genetics Ch
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Park Hyun
Department Of Computer Science Korea Advanced Institute Of Science & Technology
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Kim Eugene
Department Of Dermatology Samsung Medical Center Sungkyunkwan University School Of Medicine
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Park H
Department Of Sport Medicine Kyung-hee University
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Kim E
Department Of Food Science & Human Nutrition And Institute For Molecular Biology And Genetics Ch
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Kim Eugene
Department Of Applied Science Hongik University
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Park Hyun
Department Of Computer Science Chungnam National University
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Park Hyun
Department Of Chemical & Biomolecular Engineering Korea Advanced Institute Of Science & Tech
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Park Hyun
Department Of Ceramic Engineering Chonnam National University
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Park Hyun
Department of Biotechnology, Yeungnam University
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