Asiatic Acid Induces Colon Cancer Cell Growth Inhibition and Apoptosis through Mitochondrial Death Cascade
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概要
- 論文の詳細を見る
Cancer is one of the leading causes of death in the world. The triterpenoid compound asiatic acid derived from the tropical medicinal plant Centella asiatica displays cytotoxic activity on fibroblast cells and several other kinds of cells. The present work studies asiatic acid-mediated growth inhibition of cancer cells and the underlying mechanism. Asiatic acid markedly inhibited cancer cell proliferation. Apoptosis of SW480 human colon cancer cells was induced by asiatic acid as shown by flow cytometry, DNA fragmentation and nuclear chromatin condensation experiments. Through increasing mitochondrial membrane permeability and cytochrome c release from mitochondria into cytosol, asiatic acid induced caspase-9 activity, which further activated caspase-3 and poly(ADP-ribose) polymerase cleavage resulting in irreversible apoptotic death in the tumor cells. Taken together, these results suggest that mitochondrial death apoptosis cascade plays very important roles in asiatic acid-induced cancer apoptosis.
- 日本薬学会の論文
著者
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Park Hyun
Department of Systems Innovation, Graduate School of Engineering, The University of Tokyo
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YANG Xin-Ying
Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine
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TANG Xue-Lian
Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine
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Jung Hyun-Ju
College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University
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Kim Sung-Yeon
College of Pharmacy, Wonkwang University
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Jung Suk-Yul
Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine
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Choi Du-Young
Department of Pediatrics, Wonkwang University School of Medicine
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Park Won-Cheol
Department of Surgery, Wonkwang University School of Medicine
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Park Won-cheol
Department Of Surgery Wonkwang University School Of Medicine
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Park Hyun
Department Of Computer Science Korea Advanced Institute Of Science & Technology
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Jung Hyun-ju
College Of Oriental Medicine And Institute Of Oriental Medicine Kyung Hee University
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Park Hyun
Department Of Computer Science Chungnam National University
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Park Hyun
Department Of Ceramic Engineering Chonnam National University
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Park Hyun
Department of Biotechnology, Yeungnam University
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