A Combination of Molecular Probe-Tandem Electrospray Ionization Mass Spectrometry : A Technique for Tracing Structural Changes in Phospholipid Hydroperoxides

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概要

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• An ethyl-labeled phosphatidylcholine hydroperoxide (PC-OOH/Et 2) was synthesized as a molecular probe for naturally occurring PC-OOH 1. Applying the precursor ion scan mode in tandem ESI mass spectrometry at m⁄z 198, a signal of the PC-OOH/Et 2 alone could be selectively detected even in the presence of a large excess of a complex mixture of phospholipids in the blood. Furthermore, molecular species that formed from PC-OOH/Et 2 by its degradation in the blood were also observed in the same spectrum. Since the molecular probe-and-mass spectrometry-assisted analytical method presented herein requires no separation process by HPLC or TLC and is speedy, requiring less than 1 h, it may be useful in lipid analysis.

• 社団法人 日本農芸化学会の論文
• 2009-03-23

著者

• Nakajima S

  Graduate School Of Natural Science And Technology Okayama University

• Baba N

  Graduate School Of Natural Science And Technology Okayama University

• Baba Naomichi

  Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University

• 田原 哲士

  Crest 科学技術振興事業団

• Tahara S

  Department Of Applied Bioscience Faculty Of Agriculture Hokkaido University

• Tahara Satoshi

  Hokkaido Univ. Sapporo Jpn

• Tahara S

  Hokkaido Univ. Sapporo Jpn

• Tahara Satoshi

  Faculty Of Agriculture Hokkaido University

• Tahara Satoshi

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University:crest Japan Scienc

• Kawanami Takako

  Redox Regulation Research Group Tokyo Metropolitan Institute Of Gerontology

• KANEKO Takao

  Tokyo Metropolitan Institute of Gerontology

• Tahara Shoichi

  Tokyo Metropolitan Institute of Gerontology

• Izumi Minoru

  Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.

• Nakajima Shuhei

  Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.

• Takiguchi Soichi

  Division Of Clinical Research National Kyushu Cancer Center

• Kaneko T

  National Inst. Agrobiological Sci. Ibaraki Jpn

• Kaneko Takao

  Tokyo Metropolitan Inst. Of Gerontology

• Kosugi Tomoko

  Faculty Of Agriculture Okayama University

• Baba Naomichi

  Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.

• Tahara S

  Tokyo Metropolitan Inst. Of Gerontology

• Tahara Shoichi

  Redox Regulation Research Group Tokyo Metropolitan Institute Of Gerontology

• IZUMI Minoru

  Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• NAKAJIMA Shuhei

  Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• BABA Naomichi

  Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• IMURA Megumi

  Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• ONYANGO Arnold

  Department of Food Science and Postharvest Technology, Jomo Kenyatta University of Agriculture and T

• Izumi Minoru

  Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University

• Imura Megumi

  Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University

• Onyango Arnold

  Department Of Food Science And Postharvest Technology Jomo Kenyatta University Of Agriculture And Te

• Baba Naomichi

  Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University

• SHIMIZU Rumiko

  Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• NAGAI Ai

  Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• TOMINAGA Hiroko

  Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University

• Shimizu Rumiko

  Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University

• Tominaga Hiroko

  Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University

• Nagai Ai

  Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University

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