Protective Effect of Phenolic Antioxidants on the Cytotoxicity Induced by Phosphatidylcholine Hydroperoxide
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概要
- 論文の詳細を見る
Phosphatidylcholine hydroperoxides show weak but distinct toxicity toward cultured human umbilical vein endothelial cells. The protective effect of phenolic antioxidants against the cytotoxicity of phosphatidylcholine hydroperoxides was examined. Probucol depressed the toxicity most effectively among the antioxidants studied under both pretreatment and concurrent treatment conditions. α-Tocopherol showed a protective effect in the case of concurrent treatment. Protection by phenolic antioxidants against the cytotoxicity of phosphatidylcholine hydroperoxides seems to depend on their incorporation rate into cells, their affinity for phospholipids, their antioxidative activity, and their orientation in membranes.
- 社団法人日本農芸化学会の論文
- 2000-06-23
著者
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Baba Naomichi
Faculty of Agriculture, Okayama University
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Baba N
Graduate School Of Natural Science And Technology Okayama University
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Baba Naomichi
Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University
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Baba Naomichi
Faculty Of Agriculture Okayama University
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Kawanami Takako
Redox Regulation Research Group Tokyo Metropolitan Institute Of Gerontology
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KANEKO Takao
Tokyo Metropolitan Institute of Gerontology
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Matsuo Mitsuyoshi
Tokyo Metropolitan Institute of Gerontology
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Kaneko T
Department Of Pharmaceutical Science Hiroshima International University
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Kaneko T
National Inst. Agrobiological Sci. Ibaraki Jpn
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Kaneko Takao
Tokyo Metropolitan Inst. Of Gerontology
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Kosugi Tomoko
Faculty Of Agriculture Okayama University
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Baba Naomichi
Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.
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MATSUO Mitsuyoshi
Faculty of Science and High Technology Center, Konan University
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Matsuo Mitsuyoshi
Department Of Biology Faculty Of Science Konan University
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