Synthesis of the Photoaffinity-labeled Grayanotoxins for Studying the Gating Mechanism of Na Channel

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概要

• 論文の詳細を見る

• Grayanotoxin loosely binds to the neurotoxin receptor site 2 on Na channels. 14R-N-[4-(1-Azi-2,2,2-trifluoroethyl)]benzyliminograyanotoxane-3β, 5,6β, 16-tetraol (4) and 17-N-[4-(1-Azi-2,2,2-trifluoroethyl)]-benzyliminograyanotox-15-ene-3β, 5,6β, 14R-tetraol (5) were synthesized and applied intracellularly to squid axons. On UV irradiation, their membrane potential produced by a dose of 4 or 5 rose to higher level than that in the dark. However, in the case of 5,even when the axons were internally perfused with toxin-free solution after the dose, the potential level did not fall in contrast to 4. It suggested that 5 covalently bound to the receptor involved in the gating mechanism of Na channels.

• 社団法人日本農芸化学会の論文
• 1992-07-23

著者

• Nakajima S

  Graduate School Of Natural Science And Technology Okayama University

• IWASA Junkichi

  Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University

• Seyama Issei

  Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University

• Seyama I

  Hiroshima Univ. Hiroshima Jpn

• Kamano Hideki

  Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University

• Baba Naomichi

  Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.

• Iwasa J

  Okayama Univ.

• IWASA Junkichi

  Bioresources Chemistry, Faculty of Agriculture, Okayama University

• KAMANO Hideki

  Bioresources Chemistry, Faculty of Agriculture, Okayama University

• TSUJI Katsuso

  Department of Physiology, School of Medicine, Hiroshima University

• BABA Naomichi

  Bioresources Chemistry, Faculty of Agriculture, Okayama University

• NAKAJIMA Shuhei

  Bioresources Chemistry, Faculty of Agriculture, Okayama University

• Tsuji Katsuso

  Department Of Physiology School Of Medicine Hiroshima University

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