Flavonoids Suppress the Cytotoxicity of Linoleic Acid Hydroperoxide toward PC12 Cells

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概要

• 論文の詳細を見る

• The suppressive effect of fiavonoids on the cytotoxicity of linoleic acid hydroperoxide (LOOH) toward rat phenochromocytoma PC12 cells was examined. The extent of cytotoxicity was shown on the basis of % survival determined by the trypan blue exclusion test. On preincubation of cells with either 3-hydroxyflavone, quercetin, or luteolin prior to LOOH exposure, the cytotoxicity was considerably suppressed. In contrast, on coincubation of cells with either eriodictyol, quercetin, knempherol, luteolin, or 3-hydroxyflavone and LOOH, it was markedly suppressed. Regardless of incubation conditions, quercetin, 3-hydroxyflavone, and luteolin were thus more effetive as protective agents against the cytotoxicity than the other flavonoids. These flavonoids further showed a suppressive effect on coincubation rather than on preincubation. These results suggest that such flavonoids are beneficial for cells under oxidative stress.

• 公益社団法人日本薬学会の論文
• 2002-08-01

著者

• Baba N

  Graduate School Of Natural Science And Technology Okayama University

• Baba Naomichi

  Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University

• Baba Naomichi

  Department Of Biore Sources Chemistry Faculty Of Agriculture Okayama University

• Kawanami Takako

  Redox Regulation Research Group Tokyo Metropolitan Institute Of Gerontology

• KANEKO Takao

  Tokyo Metropolitan Institute of Gerontology

• Matsuo Mitsuyoshi

  Tokyo Metropolitan Institute of Gerontology

• Toda Takeshi

  Department of Radiation Biology and Medical Genetics, Osaka University Graduate School of Medicine

• Kaneko T

  Department Of Pharmaceutical Science Hiroshima International University

• Toda Takeshi

  Department Of Biology Faculty Of Science And High Technology Research Center Konan University

• Kaneko T

  National Inst. Agrobiological Sci. Ibaraki Jpn

• Kaneko Takao

  Tokyo Metropolitan Inst. Of Gerontology

• Baba Naomichi

  Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.

• Sasaki N

  Kyoto Univ. Kyoto

• Sasaki Naoko

  Department Of Biology Faculty Of Science And High Technology Research Center Konan University

• MATSUO Mitsuyoshi

  Department of Biology, Faculty of Science and High Technology Research Center, Konan University

• Matsuo Mitsuyoshi

  Department Of Biology Faculty Of Science And High Technology Research Center Konan University

• Matsuo Mitsuyoshi

  Department Of Biology Faculty Of Science Konan University

• Toda Takeshi

  Department Of Applied Chemistry School Of Engineering Nagoya University

• BABA Naomichi

  Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University

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