DEVELOPMENTAL TOXICITY POTENTIAL OF GRAYANOTOXIN I IN MICE AND CHICKS

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概要

• 論文の詳細を見る

• Developmental toxicity potential of grayanotoxin I (GTX I), a toxic diterpenoid contained in plants of the family Ericaceae, with sodium ionophore activity, was studied in mice and chicks. In mice, intraperitoneal injections of 1.5 mg GTX I/kg body weight of mouse for three consecutive days during the organogenetic period caused some dams to die, but neither embryotoxicity nor teratogenicity was detected. In chicks, a single injection of 0.1-1.0 μg GTX I per egg into the extraembryonic coelom on day 1.5 or 2 of incubation, or into the amnionic cavity on day 3 or 4 of incubation induced neither embryotoxic nor teratogenic signs, but 10μg GTX I per egg showed lethal effects when applied on eath of those days.

• 日本トキシコロジー学会の論文
• 1990-11-26

著者

• Seyama I

  Hiroshima Univ. Hiroshima Jpn

• Seyama Issei

  First Department Of Physiology Hiroshima University School Of Medicine

• Yasuda Mineo

  Faculty Of Pharmaceutical Sciences Setsunan University

• KOBAYASHI Takashi

  First Department of Anatomy, Hiroshima University School of Medicine

• YASUDA Mineo

  First Department of Anatomy, Hiroshima University School of Medicine

• Yasuda Mineo

  First Department Of Anatomy Hiroshima University School Of Medicine

関連論文

• Synthesis of Photoaffinity and Tritium-labeled Grayanotoxin via Reductive Amination
• Point-Mutations Related to the Loss of Batrachotoxin Binding Abolish the Grayanotoxin Effect in Na^+ Channel Isoforms
• DEVELOPMENTAL TOXICITY POTENTIAL OF GRAYANOTOXIN I IN MICE AND CHICKS
• Synthesis of the Photoaffinity-labeled Grayanotoxins for Studying the Gating Mechanism of Na Channel
• The Anatomic Relation Among the Nerve Roots, Intervertebral Foramina, and Intervertebral Discs of the Cervical Spine

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